The Wnt pathway is central to a host of developmental and disease-related processes. The
remarkable conservation of this intercellular signaling cascade throughout metazoan …

The WNT–β-catenin system is an evolutionary conserved signalling pathway that is of
particular importance for morphogenesis and cell organization during embryogenesis. The …

Intercellular signaling molecules, known as morphogens, act at a long range in developing
tissues to provide spatial information and control properties such as cell fate and tissue …

The WNT signal transduction cascade is a main regulator of development throughout the
animal kingdom. Wnts are also key drivers of most types of tissue stem cells in adult …

From bacteria to humans, cells secrete a large variety of membrane-bound extracellular
vesicles. Only relatively recently has it however started to become clear that the exovesicular …

WNT2 acts as a pro-angiogenic factor in placental vascularization and increases
angiogenesis in liver sinusoidal endothelial cells (ECs) and other ECs. Increased WNT2 …

WNT signaling is an elaborate and complex collection of signal transduction pathways
mediated by multiple signaling molecules. WNT signaling is critically important for …

Across complex, multi-time and-length scale biological systems, redundancy confers
robustness and resilience, enabling adaptation and increasing survival under dynamic …

This review discusses recent advances in our understanding of the role filopodia and
filopodia-like structures in cell adhesion and three dimensional (3D) cell migration both in …

Wnts and R-spondins (RSPOs) support intestinal homeostasis by regulating crypt cell
proliferation and differentiation. Ex vivo, Wnts secreted by Paneth cells in organoids can …