Sickle cell disease (SCD) is an inherited hemoglobinopathy in which affected hemoglobin
polymerizes under hypoxic conditions resulting in red cell distortion and chronic hemolytic …

Although past trials of optimal transfusion thresholds have focused on Hb as a singular
marker for transfusion needs, measures of oxygenation (via NIRS or specialized MRI) and …

Children with sickle cell disease (SCD) demonstrate cerebral hemodynamic stress and are
at high risk of strokes. We hypothesized that curative hematopoietic stem cell transplant …

Chronic anemia is commonly observed in patients with hemoglobinopathies, mainly
represented by disorders of altered hemoglobin (Hb) structure (sickle cell disease, SCD) …

In this issue of Blood, Hulbert and colleagues demonstrate the normalization of cerebral
hemodynamics following hematopoietic stem cell transplantation (HSCT) in 10 children with …

Voxelotor is an inhibitor of sickle hemoglobin polymerization that is used to treat sickle cell
disease. Although voxelotor has been shown to improve anemia, the clinical benefit on the …

Conclusion Patients with SCD suffer from a host of neurologic complications of their disease,
including cognitive dysfunction in the absence of concomitant stroke. While the …

Purpose There are many approaches to the quantitative BOLD (qBOLD) technique
described in the literature, differing in pulse sequences, MRI parameters and data …

Sickle cell disease (SCD) is complicated by silent cerebral infarcts (SCIs), for which anemia
is an important risk factor. Despite normal oxygen delivery (OD), cerebral vascular reserve …

Objective Cerebral venous oxygenation (Y v) is a key parameter for the brain's oxygen
utilization and has been suggested to be a valuable biomarker in various brain diseases …