Arsenic toxicity: molecular targets and therapeutic agents
High arsenic (As) levels in food and drinking water, or under some occupational conditions,
can precipitate chronic toxicity and in some cases cancer. Millions of people are exposed to …
can precipitate chronic toxicity and in some cases cancer. Millions of people are exposed to …
Neurotoxicity linked to dysfunctional metal ion homeostasis and xenobiotic metal exposure: redox signaling and oxidative stress
Significance: Essential metals such as copper, iron, manganese, and zinc play a role as
cofactors in the activity of a wide range of processes involved in cellular homeostasis and …
cofactors in the activity of a wide range of processes involved in cellular homeostasis and …
Arsenic-induced neurotoxicity: a mechanistic appraisal
Arsenic is a metalloid found in groundwater as a byproduct of soil/rock erosion and industrial
and agricultural processes. This xenobiotic elicits its toxicity through different mechanisms …
and agricultural processes. This xenobiotic elicits its toxicity through different mechanisms …
Role of metallic pollutants in neurodegeneration: effects of aluminum, lead, mercury, and arsenic in mediating brain impairment events and autism spectrum disorder
Autism spectrum disorder (ASD) is a developmental disorder of the brain characterized by
shortfall in the social portfolio of an individual and abbreviated interactive and …
shortfall in the social portfolio of an individual and abbreviated interactive and …
Toxic metal (loid)-based pollutants and their possible role in autism spectrum disorder
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by deficits
in social interaction, verbal and non-verbal communication, and stereotypic behaviors. Many …
in social interaction, verbal and non-verbal communication, and stereotypic behaviors. Many …
Toxicity mechanisms of arsenic that are shared with neurodegenerative diseases and cognitive impairment: Role of oxidative stress and inflammatory responses
C Escudero-Lourdes - Neurotoxicology, 2016 - Elsevier
Arsenic (As) is a worldwide naturally occurring metalloid. Human chronic exposure to
inorganic As compounds (iAs), which are at the top of hazardous substances (ATSDR …
inorganic As compounds (iAs), which are at the top of hazardous substances (ATSDR …
Arsenic exposure and non-carcinogenic health effects
M Martínez-Castillo… - Human & …, 2021 - journals.sagepub.com
Inorganic arsenic (iAs) exposure is a serious health problem that affects more than 140
million individuals worldwide, mainly, through contaminated drinking water. Acute iAs …
million individuals worldwide, mainly, through contaminated drinking water. Acute iAs …
Glutamate transporters: Critical components of glutamatergic transmission
AG Rodríguez-Campuzano, A Ortega - Neuropharmacology, 2021 - Elsevier
Glutamate is the major excitatory neurotransmitter in the vertebrate central nervous system.
Once released, it binds to specific membrane receptors and transporters activating a wide …
Once released, it binds to specific membrane receptors and transporters activating a wide …
Transcriptional regulation of glutamate transporters: from extracellular signals to transcription factors
Z Martinez-Lozada, AM Guillem… - Advances in pharmacology, 2016 - Elsevier
Glutamate is the predominant excitatory neurotransmitter in the mammalian CNS. It
mediates essentially all rapid excitatory signaling. Dysfunction of glutamatergic signaling …
mediates essentially all rapid excitatory signaling. Dysfunction of glutamatergic signaling …
Arundic acid increases expression and function of astrocytic glutamate transporter EAAT1 via the ERK, Akt, and NF-κB pathways
P Karki, P Hong, J Johnson, E Pajarillo, DS Son… - Molecular …, 2018 - Springer
Glutamate is the major excitatory neurotransmitter in the brain, but excessive synaptic
glutamate must be removed to prevent excitotoxic injury and death. Two astrocytic glutamate …
glutamate must be removed to prevent excitotoxic injury and death. Two astrocytic glutamate …