Life as we know it, simply would not exist without DNA replication. All living organisms utilize
a complex machinery to duplicate their genomes and the central role in this machinery …

SUMMARY DNA repair and DNA damage tolerance machineries are crucial to overcome
the vast array of DNA damage that a cell encounters during its lifetime. In this review, we …

▪ Abstract This review focuses on eukaryotic translesion synthesis (TLS) DNA polymerases,
and the emphasis is on Saccharomyces cerevisiae and human Y-family polymerases (Pols) …

Living cells are continually exposed to DNA-damaging agents that threaten their genomic
integrity. Although DNA repair processes rapidly target the damaged DNA for repair, some …

▪ Abstract DNA repair is crucial to the well-being of all organisms from unicellular life forms to
humans. A rich tapestry of mechanistic studies on DNA repair has emerged thanks to the …

Living organisms are continually under attack from a vast array of DNA-damaging agents
that imperils their genomic integrity. As a consequence, cells posses an army of enzymes to …

Y-Family DNA polymerases specialize in translesion synthesis, bypassing damaged bases
that would otherwise block the normal progression of replication forks. Y-Family …

Cellular DNA is continually damaged by a plethora of extrinsic and intrinsic sources,
including UV light from the sun and reactive oxygen species resulting from aerobic …

On careful examination of existing kinetic data for correct and incorrect dNTP incorporations
by a variety of DNA polymerases, it is apparent that these enzymes resist a unified …

Almost all DNA polymerases show a strong preference for incorporating the nucleotide that
forms the correct Watson–Crick base pair with the template base. In addition, the catalytic …