Insulin resistance, defined as a defect in insulin-mediated control of glucose metabolism in
tissues—prominently in muscle, fat and liver—is one of the earliest manifestations of a …

In mammals, the white adipocyte is a cell type that is specialized for storage of energy (in the
form of triacylglycerols) and for energy mobilization (as fatty acids). White adipocyte …

Polycystic ovary syndrome (PCOS) is a common endocrine disorder characterized by
chronic ovulation dysfunction and overabundance of androgens; it affects 6–20% of women …

A family of facilitative glucose transporters (GLUTs) is involved in regulating tissue-specific
glucose uptake and metabolism in the liver, skeletal muscle, and adipose tissue to ensure …

Lipids are essential metabolites, which function as energy sources, structural components
and signalling mediators. Most cells are able to convert carbohydrates into fatty acids, which …

The 1921 discovery of insulin was a Big Bang from which a vast and expanding universe of
research into insulin action and resistance has issued. In the intervening century, some …

Metformin is the most commonly used treatment to increase insulin sensitivity in insulin-
resistant (IR) conditions such as diabetes, prediabetes, polycystic ovary syndrome, and …

Adipocyte Regulation of Insulin Sensitivity and the Risk of Type 2 Diabetes | New England Journal
of Medicine Skip to main content The New England Journal of Medicine homepage Advanced …

The epidemic of obesity contributes to the burden of type 2 diabetes mellitus (T2DM) in the
United States and worldwide. Importantly, obesity is not only preventable but can be treated …

The subcutaneous adipose tissue (SAT) is the largest and best storage site for excess lipids.
However, it has a limited ability to expand by recruiting and/or differentiating available …