Cell–extracellular matrix mechanotransduction in 3D

A Saraswathibhatla, D Indana… - Nature Reviews Molecular …, 2023 - nature.com
Mechanical properties of extracellular matrices (ECMs) regulate essential cell behaviours,
including differentiation, migration and proliferation, through mechanotransduction. Studies …

Engineered hydrogels for mechanobiology

U Blache, EM Ford, B Ha, L Rijns… - Nature Reviews …, 2022 - nature.com
Cells' local mechanical environment can be as important in guiding cellular responses as
many well-characterized biochemical cues. Hydrogels that mimic the native extracellular …

Volumetric bioprinting of organoids and optically tuned hydrogels to build liver‐like metabolic biofactories

PN Bernal, M Bouwmeester, J Madrid‐Wolff… - Advanced …, 2022 - Wiley Online Library
Organ‐and tissue‐level biological functions are intimately linked to microscale cell–cell
interactions and to the overarching tissue architecture. Together, biofabrication and …

Engineered biomaterials for in situ tissue regeneration

AK Gaharwar, I Singh, A Khademhosseini - Nature Reviews Materials, 2020 - nature.com
In situ tissue regeneration harnesses the body's regenerative potential to control cell
functions for tissue repair. The design of biomaterials for in situ tissue engineering requires …

The living interface between synthetic biology and biomaterial design

AP Liu, EA Appel, PD Ashby, BM Baker, E Franco… - Nature materials, 2022 - nature.com
Recent far-reaching advances in synthetic biology have yielded exciting tools for the
creation of new materials. Conversely, advances in the fundamental understanding of soft …

Enhanced mechanosensing of cells in synthetic 3D matrix with controlled biophysical dynamics

B Yang, K Wei, C Loebel, K Zhang, Q Feng, R Li… - Nature …, 2021 - nature.com
Abstract 3D culture of cells in designer biomaterial matrices provides a biomimetic cellular
microenvironment and can yield critical insights into cellular behaviours not available from …

Mechanics of 3D cell–hydrogel interactions: experiments, models, and mechanisms

FJ Vernerey, S Lalitha Sridhar, A Muralidharan… - Chemical …, 2021 - ACS Publications
Hydrogels are highly water-swollen molecular networks that are ideal platforms to create
tissue mimetics owing to their vast and tunable properties. As such, hydrogels are promising …

Local nascent protein deposition and remodelling guide mesenchymal stromal cell mechanosensing and fate in three-dimensional hydrogels

C Loebel, RL Mauck, JA Burdick - Nature materials, 2019 - nature.com
Hydrogels serve as valuable tools for studying cell–extracellular matrix interactions in three-
dimensional environments that recapitulate aspects of native extracellular matrix. However …

Robust hydrogel sensors for unsupervised learning enabled sign‐to‐verbal translation

H Ma, H Qin, X Xiao, N Liu, S Wang, J Li, S Shen… - InfoMat, 2023 - Wiley Online Library
Highly stretchable and robust strain sensors are rapidly emerging as promising candidates
for a diverse of wearable electronics. The main challenge for the practical application of …

The overview of porous, bioactive scaffolds as instructive biomaterials for tissue regeneration and their clinical translation

G Lutzweiler, A Ndreu Halili, N Engin Vrana - Pharmaceutics, 2020 - mdpi.com
Porous scaffolds have been employed for decades in the biomedical field where
researchers have been seeking to produce an environment which could approach one of …