A guide for developing comprehensive systems biology maps of disease mechanisms: planning, construction and maintenance
A Mazein, ML Acencio, I Balaur, A Rougny… - Frontiers in …, 2023 - frontiersin.org
As a conceptual model of disease mechanisms, a disease map integrates available
knowledge and is applied for data interpretation, predictions and hypothesis generation. It is …
knowledge and is applied for data interpretation, predictions and hypothesis generation. It is …
The phosphatase PRL-3 is involved in key steps of cancer metastasis
L Duciel, LCM Gomez, M Kondratova… - Journal of molecular …, 2019 - Elsevier
PRL-3 belongs to the PRL phosphatase family. Its physiological role remains unclear, but
many studies have identified that PRL-3 is a marker of cancer progression and shown it to …
many studies have identified that PRL-3 is a marker of cancer progression and shown it to …
Pathway information extracted from 25 years of pathway figures
Thousands of pathway diagrams are published each year as static figures inaccessible to
computational queries and analyses. Using a combination of machine learning, optical …
computational queries and analyses. Using a combination of machine learning, optical …
A multiscale signalling network map of innate immune response in cancer reveals cell heterogeneity signatures
The lack of integrated resources depicting the complexity of the innate immune response in
cancer represents a bottleneck for high-throughput data interpretation. To address this …
cancer represents a bottleneck for high-throughput data interpretation. To address this …
Mechanistic computational models of microRNA-mediated signaling networks in human diseases
MicroRNAs (miRs) are endogenous non-coding RNA molecules that play important roles in
human health and disease by regulating gene expression and cellular processes. In recent …
human health and disease by regulating gene expression and cellular processes. In recent …
CyFi-MAP: an interactive pathway-based resource for cystic fibrosis
Cystic fibrosis (CF) is a life-threatening autosomal recessive disease caused by more than
2100 mutations in the CF transmembrane conductance regulator (CFTR) gene, generating …
2100 mutations in the CF transmembrane conductance regulator (CFTR) gene, generating …
Modelling of immune checkpoint network explains synergistic effects of combined immune checkpoint inhibitor therapy and the impact of cytokines in patient response
Simple Summary The future of cancer immunotherapy relies on a combination of individually
targeted therapies. However, a lot of experiments are needed to define the most effective …
targeted therapies. However, a lot of experiments are needed to define the most effective …
Using interactive platforms to encode, manage and explore immune-related adverse outcome pathways
We address the need for modelling and predicting adverse outcomes in immunotoxicology
to improve non-clinical assessments of immunomodulatory therapy safety and efficacy. The …
to improve non-clinical assessments of immunomodulatory therapy safety and efficacy. The …
In-silico modelling of the mitogen-activated protein kinase (MAPK) pathway in colorectal cancer: mutations and targeted therapy
S Sommariva, S Berra, G Biddau, G Caviglia… - Frontiers in Systems …, 2023 - frontiersin.org
Introduction: Chemical reaction networks (CRNs) are powerful tools for describing the
complex nature of cancer's onset, progression, and therapy. The main reason for their …
complex nature of cancer's onset, progression, and therapy. The main reason for their …
Converting disease maps into heavyweight ontologies: general methodology and application to Alzheimer's disease
V Henry, I Moszer, O Dameron, L Vila Xicota… - Database, 2021 - academic.oup.com
Omics technologies offer great promises for improving our understanding of diseases. The
integration and interpretation of such data pose major challenges, calling for adequate …
integration and interpretation of such data pose major challenges, calling for adequate …