In the past decades the incidence of colorectal cancer (CRC) in people under the age of 50
years has increased, which is referred to as early-onset CRC or young-onset CRC (YO …

Over the past several decades, the incidence of early-onset cancers, often defined as
cancers diagnosed in adults< 50 years of age, in the breast, colorectum, endometrium …

Colorectal cancer (CRC) epidemiology is changing due to a birth cohort effect, first
recognized by increasing incidence of early onset CRC (EOCRC, age< 50 years). In this …

Accumulating evidence indicates an alarming increase in the incidence of early-onset
cancers, which are diagnosed among adults under 50 years of age, in the colorectum …

Obesity results from a chronic excessive accumulation of adipose tissue due to a long-term
imbalance between energy intake and expenditure. Available epidemiological and clinical …

The prevalence of obesity has reached pandemic levels worldwide, leading to a lower
quality of life and higher health costs. Obesity is a major risk factor for noncommunicable …

Metabolic reprogramming has been considered a core hallmark of cancer, in which
excessive accumulation of lipids promote cancer initiation, progression and metastasis …

Importance The incidence of early-onset colorectal cancer (CRC), diagnosed younger than
50 years of age, has increased worldwide. Gut dysbiosis throughout the life course is …

The long-term consequences of maternal obesity and GDM for the offspring in childhood
and later adult life present major challenges for public health across the life course and for …

Background Incidence rates of colorectal cancer (CRC) are increasing among younger
adults and in mid-life, implicating exposures in early life as risk factors. We examined the …