Ovarian cancer has the highest mortality of all of the gynecological malignancies. There are
several distinct histotypes of this malignancy characterized by specific molecular events and …

Immunogenic cell death (ICD) is a functionally unique form of cell death that promotes a T-
cell-dependent anti-tumor immune response specific to antigens originating from dying …

Background Breast cancer is the most common cause of cancer related deaths in women.
Treatment of breast cancer has many limitations including a lack of accurate biomarkers to …

Living therapeutics approaches that exploit mesenchymal stem cells (MSCs) as
nanomedicine carriers are highly attractive due to MSCs native tropism toward the 3D tumor …

Three-dimensional (3D) spheroid models are rapidly gaining favor for drug discovery
applications due to their improved morphological characteristics, cellular complexity, long …

Simple Summary Traditional preclinical testing, including 2D cell culture and animal models,
often fails to accurately predict drug efficacy in humans, especially for oncology drugs …

Based on our exponentially increasing knowledge of stromal heterogeneity from advances
in single-cell technologies, the notion that stromal cell types exist as a spectrum of unique …

Cancer-associated fibroblasts (CAFs) are key contributors to ovarian cancer (OC)
progression and therapeutic resistance through dysregulation of the extracellular matrix …

Introduction Solid tumors are highly influenced by a complex tumor microenvironment (TME)
that cannot be modeled with conventional two-dimensional (2D) cell culture. In addition …

Plexiform neurofibromas (pNFs) are benign tumors of the peripheral nervous system (PNS)
that can progress towards a deadly soft tissue sarcoma termed malignant peripheral nerve …