Free energy simulations are a powerful tool for evaluating the interactions of molecular
solutes with lipid bilayers as mimetics of cellular membranes. However, these simulations …

Alkylphospholipids (APLs) represent a new class of drugs which do not interact directly with
DNA but act on the cell membrane where they accumulate and interfere with lipid …

Lipid membranes work as barriers, which leads to inevitable drug-membrane interactions in
vivo. These interactions affect the pharmacokinetic properties of drugs, such as their …

Miltefosine presents antineoplastic activity but high hemolytic potential. Its use in cancer has
been limited to treating cutaneous metastasis of breast cancer. To decrease hemolytic …

Scaffold proteins are ubiquitous chaperones that bind proteins and facilitate physical
interaction of multi-enzyme complexes. Here we used a biochemical approach to dissect the …

Abstract Background Conventional miltefosine dosing (2.5 mg/kg/day) for treatment of
visceral leishmaniasis (VL) is less effective in children than in adults. A higher allometric …

The evolving resistance to the currently used chemotherapeutic agents requires continuous
efforts to develop new anticancer agents overcoming resistance and with lower side effects …

Miltefosine (hexadecylphosphocholine, HePC) is a broad spectrum antimicrobial, anti-
leishmanial drug, originally developed as anti-cancer agent. Because of its toxic side effects …

A multistep computational approach has been employed to study a multimillion all-atom
dyed plasma membrane, with no less than 42 different lipid species spanning the major …

SK3 channels are abnormaly expressed in metastatic cells, and Ohmline (OHM), an ether
lipid, has been shown to reduce the activity of SK3 channels and the migration capacity of …