Human-specific genetics: new tools to explore the molecular and cellular basis of human evolution
Our ancestors acquired morphological, cognitive and metabolic modifications that enabled
humans to colonize diverse habitats, develop extraordinary technologies and reshape the …
humans to colonize diverse habitats, develop extraordinary technologies and reshape the …
Museum genomics
Natural history collections are invaluable repositories of biological information that provide
an unrivaled record of Earth's biodiversity. Museum genomics—genomics research using …
an unrivaled record of Earth's biodiversity. Museum genomics—genomics research using …
The Allen Ancient DNA Resource (AADR) a curated compendium of ancient human genomes
S Mallick, A Micco, M Mah, H Ringbauer, I Lazaridis… - Scientific Data, 2024 - nature.com
More than two hundred papers have reported genome-wide data from ancient humans.
While the raw data for the vast majority are fully publicly available testifying to the …
While the raw data for the vast majority are fully publicly available testifying to the …
Loss of extreme long-range enhancers in human neural crest drives a craniofacial disorder
Non-coding mutations at the far end of a large gene desert surrounding the SOX9 gene
result in a human craniofacial disorder called Pierre Robin sequence (PRS). Leveraging a …
result in a human craniofacial disorder called Pierre Robin sequence (PRS). Leveraging a …
Current advances in primate genomics: novel approaches for understanding evolution and disease
Primate genomics holds the key to understanding fundamental aspects of human evolution
and disease. However, genetic diversity and functional genomics data sets are currently …
and disease. However, genetic diversity and functional genomics data sets are currently …
More than a decade of genetic research on the Denisovans
Denisovans, a group of now extinct humans who lived in Eastern Eurasia in the Middle and
Late Pleistocene, were first identified from DNA sequences just over a decade ago. Only ten …
Late Pleistocene, were first identified from DNA sequences just over a decade ago. Only ten …
The Persian plateau served as hub for Homo sapiens after the main out of Africa dispersal
A combination of evidence, based on genetic, fossil and archaeological findings, indicates
that Homo sapiens spread out of Africa between~ 70-60 thousand years ago (kya) …
that Homo sapiens spread out of Africa between~ 70-60 thousand years ago (kya) …
Twenty‐first century bioarchaeology: Taking stock and moving forward
This article presents outcomes from a Workshop entitled “Bioarchaeology: Taking Stock and
Moving Forward,” which was held at Arizona State University (ASU) on March 6–8, 2020 …
Moving Forward,” which was held at Arizona State University (ASU) on March 6–8, 2020 …
Human–chimpanzee fused cells reveal cis-regulatory divergence underlying skeletal evolution
D Gokhman, RM Agoglia, M Kinnebrew, W Gordon… - Nature …, 2021 - nature.com
Gene regulatory divergence is thought to play a central role in determining human-specific
traits. However, our ability to link divergent regulation to divergent phenotypes is limited …
traits. However, our ability to link divergent regulation to divergent phenotypes is limited …
The cis-regulatory effects of modern human-specific variants
The Neanderthal and Denisovan genomes enabled the discovery of sequences that differ
between modern and archaic humans, the majority of which are noncoding. However, our …
between modern and archaic humans, the majority of which are noncoding. However, our …