An ongoing global pandemic of viral pneumonia (coronavirus disease [COVID-19]), due to
the virus SARS-CoV-2, has infected millions of people and remains a threat to many more …

There has been a significant evolution in the definition and management of sepsis over the
last three decades. This is driven in part due to the advances made in our understanding of …

For more than two decades, sepsis was defined as a microbial infection that produces fever
(or hypothermia), tachycardia, tachypnoea and blood leukocyte changes. Sepsis is now …

Background Tocilizumab is an IL-6 receptor-blocking agent proposed for the treatment of
severe COVID-19. The aim of this systematic review was to describe the rationale for the use …

A hyperinflammatory response to severe acute respiratory syndrome‐coronavirus 2 (SARS‐
CoV‐2) infection, reminiscent of cytokine release syndrome, has been implicated in the …

Septic cardiomyopathy is a key feature of sepsis-associated cardiovascular failure. Despite
the lack of consistent diagnostic criteria, patients typically exhibit ventricular dilatation …

While for a century therapeutics has been dominated by small molecules, ie organic
chemicals of~ 400Da absorbable via the gut, this is no longer the case. There are now a …

The systemic inflammatory response is biologically complex, redundant, and activated by
both infectious and noninfectious triggers. Its manipulation can cause both benefit and harm …

The use of mice as animal models has long been considered essential in modern
biomedical research, but the role of mouse models in research was challenged by a recent …

Sepsis remains a common, serious, and heterogeneous clinical entity that is difficult to
define adequately. Despite its importance as a public health problem, efforts to develop and …