Background As a source of readily available evidence, rigorously synthesized and
interpreted by expert clinicians and methodologists, clinical guidelines are part of an …

Therapeutic drug monitoring (TDM) and model‐informed precision dosing (MIPD) have
evolved as important tools to inform rational dosing of antibiotics in individual patients with …

Abstract Background Randomised controlled trials (RCTs) are considered the gold standard
when evaluating the causal effects of healthcare interventions. When RCTs cannot be used …

The Consolidated Standards of Reporting Trials (CONSORT) statement was developed to
improve the reporting of randomised controlled trials. It was initially published in 1996 and …

Neurofeedback is attracting renewed interest as a method to self-regulate one's own brain
activity to directly alter the underlying neural mechanisms of cognition and behavior. It not …

The delivery of high quality and equitable care for both mothers and newborns is complex
and requires efforts across many sectors. The United States spends more on childbirth than …

Objectives To describe the use and reporting of interrupted time series methods in drug
utilization research. Study Design and Setting We completed a systematic search of …

Improvement (defined broadly as purposive efforts to secure positive change) has become
an increasingly important activity and field of inquiry within healthcare. This article offers an …

Quasi-experimental study designs, often described as nonrandomized, pre-post intervention
studies, are common in the medical informatics literature. Yet little has been written about …

Background. Increasing recognition of the failure to translate research findings into practice
has led to greater awareness of the importance of using active dissemination and …