The development of antiretroviral drugs (ARVs) was a great milestone in the management of
HIV infection. ARVs suppress viral activity in the host cell, thus minimizing injury to the cells …

HIV-1 encodes four accesory proteins in addition to its structural and regulatory genes.
Uniquely amongst them, Vpr is abundantly present within virions, meaning it is poised to …

Understanding the mechanisms that drive HIV expression and latency is a key goal for
achieving an HIV cure. Here we investigate the role of the SETD2 histone methyltransferase …

Abstract Purpose of Review The main obstacle to an HIV-1 cure is the reservoir of HIV-1
infected cells. While antiretroviral therapy (ART) eliminates the HIV-1 virus effectively, it does …

Infection by retroviruses as HIV-1 requires the stable integration of their genome into the
host cells. This process needs the formation of integrase (IN)-viral DNA complexes, called …

The HIV-1 latent is established very early during infection, and its persistence is the major
obstacle to achieving an HIV-1 cure. Here, we present a succinct summary of the latest …

Histone H1. 2 is a member of the linker histone family, which plays extensive and crucial
roles not only in the regulation of chromatin dynamics, cell cycle, and cell apoptosis, but also …

Abstract Background and Aim Human immunodeficiency virus (HIV) remains a significant
global health challenge, with approximately 39 million people living with HIV worldwide as …

HIV-1 integration occurs across actively transcribed genes due to the interaction of integrase
with host chromatin factor LEDGF. Although LEDGF was originally isolated as a co-activator …

HIV can enter a state of transcriptional latency in CD4 T cells, allowing the virus to evade the
host immune system and persist during antiretroviral therapy. Thus, understanding the …