The multifaceted contributions of mitochondria to cellular metabolism
JB Spinelli, MC Haigis - Nature cell biology, 2018 - nature.com
Although classically appreciated for their role as the powerhouse of the cell, the metabolic
functions of mitochondria reach far beyond bioenergetics. In this Review, we discuss how …
functions of mitochondria reach far beyond bioenergetics. In this Review, we discuss how …
International union of basic and clinical pharmacology. CII: pharmacological modulation of H2S levels: H2S donors and H2S biosynthesis inhibitors
C Szabo, A Papapetropoulos - Pharmacological reviews, 2017 - ASPET
Over the last decade, hydrogen sulfide (H2S) has emerged as an important endogenous
gasotransmitter in mammalian cells and tissues. Similar to the previously characterized …
gasotransmitter in mammalian cells and tissues. Similar to the previously characterized …
[HTML][HTML] Mitochondria regulate intracellular coenzyme Q transport and ferroptotic resistance via STARD7
Coenzyme Q (or ubiquinone) is a redox-active lipid that serves as universal electron carrier
in the mitochondrial respiratory chain and antioxidant in the plasma membrane limiting lipid …
in the mitochondrial respiratory chain and antioxidant in the plasma membrane limiting lipid …
[HTML][HTML] Disorders of human coenzyme Q10 metabolism: an overview
I Hargreaves, RA Heaton, D Mantle - International journal of molecular …, 2020 - mdpi.com
Coenzyme Q10 (CoQ10) has a number of vital functions in all cells, both mitochondrial and
extramitochondrial. In addition to its key role in mitochondrial oxidative phosphorylation …
extramitochondrial. In addition to its key role in mitochondrial oxidative phosphorylation …
Gasotransmitter hydrogen sulfide signaling in neuronal health and disease
Hydrogen sulfide is a gaseous signaling molecule or gasotransmitter which plays important
roles in a wide spectrum of physiologic processes in the brain and peripheral tissues. Unlike …
roles in a wide spectrum of physiologic processes in the brain and peripheral tissues. Unlike …
The mitochondrial coenzyme Q junction and complex III: Biochemistry and pathophysiology
R Banerjee, J Purhonen, J Kallijärvi - The FEBS journal, 2022 - Wiley Online Library
Coenzyme Q (CoQ, ubiquinone) is the electron‐carrying lipid in the mitochondrial electron
transport system (ETS). In mammals, it serves as the electron acceptor for nine mitochondrial …
transport system (ETS). In mammals, it serves as the electron acceptor for nine mitochondrial …
NRF2 signalling in cytoprotection and metabolism
S Murakami, Y Kusano, K Okazaki… - British Journal of …, 2023 - Wiley Online Library
The KEAP1‐NRF2 system plays a central role in cytoprotection in defence mechanisms
against oxidative stress. The KEAP1‐NRF2 system has been regarded as a sulfur‐utilizing …
against oxidative stress. The KEAP1‐NRF2 system has been regarded as a sulfur‐utilizing …
Bioavailability of coenzyme Q10 supplements depends on carrier lipids and solubilization
G López-Lluch, J del Pozo-Cruz, A Sánchez-Cuesta… - Nutrition, 2019 - Elsevier
Objectives Bioavailability of supplements with coenzyme Q10 (CoQ 10) in humans seems to
depend on the excipients of formulations and on physiological characteristics of the …
depend on the excipients of formulations and on physiological characteristics of the …
[HTML][HTML] Metabolic targets of coenzyme Q10 in mitochondria
A Hidalgo-Gutiérrez, P González-García… - Antioxidants, 2021 - mdpi.com
Coenzyme Q10 (CoQ10) is classically viewed as an important endogenous antioxidant and
key component of the mitochondrial respiratory chain. For this second function, CoQ …
key component of the mitochondrial respiratory chain. For this second function, CoQ …
Primary Coenzyme Q deficiencies: A literature review and online platform of clinical features to uncover genotype-phenotype correlations
M Alcázar-Fabra, F Rodríguez-Sánchez… - Free Radical Biology …, 2021 - Elsevier
Abstract Primary Coenzyme Q (CoQ) deficiencies are clinically heterogeneous conditions
and lack clear genotype-phenotype correlations, complicating diagnosis and prognostic …
and lack clear genotype-phenotype correlations, complicating diagnosis and prognostic …