Cell cycle-dependent gene transcription is tightly controlled by the retinoblastoma (RB): E2F
and DREAM complexes, which repress all cell cycle genes during quiescence. Cyclin …

Perfectly orchestrated periodic gene expression during cell cycle progression is essential for
maintaining genome integrity and ensuring that cell proliferation can be stopped by …

Curcumenol, an effective ingredient of Wenyujin, has been reported that exerted its
antitumor potential in a few cancer types. However, the effect and molecular mechanism of …

Background & Aims Despite recent progress in identifying aberrant genetic and epigenetic
alterations in esophageal squamous cell carcinoma (ESCC), the mechanism of ESCC …

Currently, there is no sensitive prognostic biomarker to screen out benefit patients from the
non-benefit population in advanced non-small cell lung cancer patients (aNSCLCs). The …

PCLAF (PCNA clamp-associated factor), also known as PAF15/KIAA0101, is overexpressed
in most human cancers and is a predominant regulator of tumor progression. However, its …

Lung cancer has the highest mortality rate amongst all malignancies worldwide, and is the
second-highest incidence of cancer in women. Non-small cell lung cancer (NSCLC) is …

Cancer is a leading cause of disease-related mortality worldwide. Drug resistance is one of
the primary reasons for the failure of anticancer therapy. There are a number of underlying …

Background: Epithelial-mesenchymal transition (EMT) is a critical process in tumor invasion
and metastasis. EMT has been shown to significantly influence the invasion, metastasis, and …

Proteasome subunit hRpn13 is partially proteolyzed in certain cancer cell types to generate
hRpn13Pru by degradation of its UCHL5/Uch37-binding DEUBAD domain and retention of …