How phagocytes find invading microorganisms and eliminate pathogenic ones from human
bodies is a fundamental question in the study of infectious diseases. About 2.5 billion years …

Ras has been extensively studied as a promoter of cell proliferation, whereas few studies
have explored its role in migration. To investigate the direct and immediate effects of Ras …

Movement of cells and tissues is essential at various stages during the lifetime of an
organism, including morphogenesis in early development, in the immune response to …

What is the underlying diffusion process governing the spreading dynamics and search
strategies employed by amoeboid cells? Based on the statistical analysis of experimental …

Quantitative systems pharmacology (QSP) modeling has become increasingly important in
pharmaceutical research and development, and is a powerful tool to gain mechanistic …

Movement of cells and tissues is a basic biological process that is used in development,
wound repair, the immune response to bacterial invasion, tumour formation and metastasis …

During the last decade, a consensus has emerged that the stochastic triggering of an
excitable system drives pseudopod formation and subsequent migration of amoeboid cells …

Movement requires force transmission to the environment, and motile cells are robustly,
though not elegantly, designed nanomachines that often can cope with a variety of …

Chemotaxis plays an essential role in recruitment of leukocytes to sites of inflammation.
Eukaryotic cells sense chemoattractant with G protein-coupled receptors (GPCRs) and …

In this work, we present a mechanobiochemical model for two-dimensional cell migration
which couples mechanical properties of the cell cytosol with biochemical processes taking …