IgG subclasses and allotypes: from structure to effector functions
Of the five immunoglobulin isotypes, immunoglobulin G (IgG) is most abundant in human
serum. The four subclasses, IgG1, IgG2, IgG3, and IgG4, which are highly conserved, differ …
serum. The four subclasses, IgG1, IgG2, IgG3, and IgG4, which are highly conserved, differ …
Understanding Fc receptor involvement in inflammatory diseases: from mechanisms to new therapeutic tools
S Ben Mkaddem, M Benhamou… - Frontiers in …, 2019 - frontiersin.org
Fc receptors (FcRs) belong to the ITAM-associated receptor family. FcRs control the humoral
and innate immunity which are essential for appropriate responses to infections and …
and innate immunity which are essential for appropriate responses to infections and …
NK cell-mediated antibody-dependent cellular cytotoxicity in cancer immunotherapy
Natural killer (NK) cells play a major role in cancer immunotherapies that involve tumor-
antigen targeting by monoclonal antibodies (mAbs). NK cells express a variety of activating …
antigen targeting by monoclonal antibodies (mAbs). NK cells express a variety of activating …
Decoding the human immunoglobulin G-glycan repertoire reveals a spectrum of Fc-receptor-and complement-mediated-effector activities
Glycosylation of the immunoglobulin G (IgG)-Fc tail is required for binding to Fc-gamma
receptors (FcγRs) and complement-component C1q. A variety of IgG1-glycoforms is …
receptors (FcγRs) and complement-component C1q. A variety of IgG1-glycoforms is …
Mouse and human FcR effector functions
P Bruhns, F Jönsson - Immunological reviews, 2015 - Wiley Online Library
Mouse and human FcRs have been a major focus of attention not only of the scientific
community, through the cloning and characterization of novel receptors, and of the medical …
community, through the cloning and characterization of novel receptors, and of the medical …
Fcγ receptors and immunomodulatory antibodies in cancer
The discovery of both cytotoxic T lymphocyte-associated antigen 4 (CTLA4) and
programmed cell death protein 1 (PD1) as negative regulators of antitumour immunity led to …
programmed cell death protein 1 (PD1) as negative regulators of antitumour immunity led to …
[HTML][HTML] Role of Fcγ receptors in HER2-targeted breast cancer therapy
A Musolino, WJ Gradishar, HS Rugo… - … for immunotherapy of …, 2022 - ncbi.nlm.nih.gov
Several therapeutic monoclonal antibodies (mAbs), including those targeting epidermal
growth factor receptor, human epidermal growth factor receptor 2 (HER2), and CD20 …
growth factor receptor, human epidermal growth factor receptor 2 (HER2), and CD20 …
Properties of mouse and human IgG receptors and their contribution to disease models
P Bruhns - Blood, The Journal of the American Society of …, 2012 - ashpublications.org
Impressive advances in defining the properties of receptors for the Fc portion of
immunoglobulins (FcR) have been made over the past several years. Ligand specificities …
immunoglobulins (FcR) have been made over the past several years. Ligand specificities …
The ligands for human IgG and their effector functions
Activation of the humoral immune system is initiated when antibodies recognize an antigen
and trigger effector functions through the interaction with Fc engaging molecules. The most …
and trigger effector functions through the interaction with Fc engaging molecules. The most …
The human FcγRII (CD32) family of leukocyte FcR in health and disease
JC Anania, AM Chenoweth, BD Wines… - Frontiers in …, 2019 - frontiersin.org
FcγRs have been the focus of extensive research due to their key role linking innate and
humoral immunity and their implication in both inflammatory and infectious disease. Within …
humoral immunity and their implication in both inflammatory and infectious disease. Within …