Presynaptic calcium channels: specialized control of synaptic neurotransmitter release
AC Dolphin, A Lee - Nature Reviews Neuroscience, 2020 - nature.com
Chemical synapses are heterogeneous junctions formed between neurons that are
specialized for the conversion of electrical impulses into the exocytotic release of …
specialized for the conversion of electrical impulses into the exocytotic release of …
Transcellular nanoalignment of synaptic function
At each of the brain's vast number of synapses, the presynaptic nerve terminal, synaptic cleft,
and postsynaptic specialization form a transcellular unit to enable efficient transmission of …
and postsynaptic specialization form a transcellular unit to enable efficient transmission of …
Nanodomain coupling between Ca2+ channels and sensors of exocytosis at fast mammalian synapses
E Eggermann, I Bucurenciu, SP Goswami… - Nature Reviews …, 2012 - nature.com
The physical distance between presynaptic Ca2+ channels and the Ca2+ sensors that
trigger exocytosis of neurotransmitter-containing vesicles is a key determinant of the …
trigger exocytosis of neurotransmitter-containing vesicles is a key determinant of the …
Multiple roles of calcium ions in the regulation of neurotransmitter release
E Neher, T Sakaba - Neuron, 2008 - cell.com
The intracellular calcium concentration ([Ca 2+]) has important roles in the triggering of
neurotransmitter release and the regulation of short-term plasticity (STP). Transmitter …
neurotransmitter release and the regulation of short-term plasticity (STP). Transmitter …
[HTML][HTML] Calcium channel regulation and presynaptic plasticity
WA Catterall, AP Few - Neuron, 2008 - cell.com
Voltage-gated calcium (Ca 2+) channels initiate release of neurotransmitters at synapses,
and regulation of presynaptic Ca 2+ channels has a powerful influence on synaptic strength …
and regulation of presynaptic Ca 2+ channels has a powerful influence on synaptic strength …
Vesicle pools and Ca2+ microdomains: new tools for understanding their roles in neurotransmitter release
E Neher - Neuron, 1998 - cell.com
Synapse,” intended to contrast our grasp of presynaptic Angleson and Betz (1997) quite
recently reviewed in physiology with our understanding of postsynaptic detail techniques for …
recently reviewed in physiology with our understanding of postsynaptic detail techniques for …
Nanoscale distribution of presynaptic Ca2+ channels and its impact on vesicular release during development
Y Nakamura, H Harada, N Kamasawa, K Matsui… - Neuron, 2015 - cell.com
Synaptic efficacy and precision are influenced by the coupling of voltage-gated Ca 2+
channels (VGCCs) to vesicles. But because the topography of VGCCs and their proximity to …
channels (VGCCs) to vesicles. But because the topography of VGCCs and their proximity to …
Calcium influx and transmitter release in a fast CNS synapse
JGG Borst, B Sakmann - Nature, 1996 - nature.com
CALCIUM entry through presynaptic calcium channels controls the release of
neurotransmitter1. It is not known whether the putative calcium sensor that triggers this rapid …
neurotransmitter1. It is not known whether the putative calcium sensor that triggers this rapid …
Linearized buffered Ca2+ diffusion in microdomains and its implications for calculation of [Ca2+] at the mouth of a calcium channel
M Naraghi, E Neher - Journal of Neuroscience, 1997 - Soc Neuroscience
Immobile and mobile calcium buffers shape the calcium signal close to a channel by
reducing and localizing the transient calcium increase to physiological compartments. In this …
reducing and localizing the transient calcium increase to physiological compartments. In this …
Presynaptic inhibition of elicited neurotransmitter release
LG Wu, P Saggau - Trends in neurosciences, 1997 - cell.com
Activation of presynaptic receptors for a variety of neurotransmitters and neuromodulators
inhibits transmitter release at many synapses. Such presynaptic inhibition might serve as a …
inhibits transmitter release at many synapses. Such presynaptic inhibition might serve as a …