Chemical synapses are heterogeneous junctions formed between neurons that are
specialized for the conversion of electrical impulses into the exocytotic release of …

At each of the brain's vast number of synapses, the presynaptic nerve terminal, synaptic cleft,
and postsynaptic specialization form a transcellular unit to enable efficient transmission of …

The physical distance between presynaptic Ca2+ channels and the Ca2+ sensors that
trigger exocytosis of neurotransmitter-containing vesicles is a key determinant of the …

The intracellular calcium concentration ([Ca 2+]) has important roles in the triggering of
neurotransmitter release and the regulation of short-term plasticity (STP). Transmitter …

Voltage-gated calcium (Ca 2+) channels initiate release of neurotransmitters at synapses,
and regulation of presynaptic Ca 2+ channels has a powerful influence on synaptic strength …

Synapse,” intended to contrast our grasp of presynaptic Angleson and Betz (1997) quite
recently reviewed in physiology with our understanding of postsynaptic detail techniques for …

Synaptic efficacy and precision are influenced by the coupling of voltage-gated Ca 2+
channels (VGCCs) to vesicles. But because the topography of VGCCs and their proximity to …

CALCIUM entry through presynaptic calcium channels controls the release of
neurotransmitter1. It is not known whether the putative calcium sensor that triggers this rapid …

Immobile and mobile calcium buffers shape the calcium signal close to a channel by
reducing and localizing the transient calcium increase to physiological compartments. In this …

Activation of presynaptic receptors for a variety of neurotransmitters and neuromodulators
inhibits transmitter release at many synapses. Such presynaptic inhibition might serve as a …