Although descriptions of quality of life and patient reports of mood in sickle cell disease
(SCD) have become more common in the literature, less is known about psychiatric illness …

Existing treatment for chronic pain in sickle cell disease (SCD) is opioid-dependent, which is
ineffective and carries risks. We conducted a scoping literature review to assess the size and …

This study aimed to comprehensively analyze inflammatory and autoimmune characteristics
of patients with sickle cell disease (SCD) at a steady-state condition (StSt) compared to …

Chemotherapy-induced peripheral neuropathy (CIPN) is a significant dose-limiting long-
term sequela in cancer patients undergoing treatment, often leading to discontinuation of …

Pain is the most common symptom experienced by patients with sickle cell disease (SCD)
throughout their lives and is the main cause of hospitalization. Despite the progress that has …

Problem Sickle cell crises (SCC) are recurrent, severe pain episodes experienced by people
living with sickle cell disease (SCD). Non-pharmacological interventions have been …

Introduction Acute pain episodes, also known as vaso-occlusive crises (VOC), are a major
symptom of sickle cell disease (SCD) and lead to frequent hospitalizations. The diagnosis of …

Background In patients who experience frequent vaso-occlusive crises (VOC), opioid
dependence may be due to a need for pain control as opposed to addiction; the implications …

Background Pain is a common, debilitating, and poorly understood complication of sickle
cell disease (SCD). The need for clinical pain management of SCD is largely unmet and …

To evaluate the safety and efficacy of L-glutamine in reducing vaso-occlusive crisis (VOC)
and improving cerebral arterial blood flow in children with sickle cell disease (SCD). This is …