[HTML][HTML] Advances in hydrogel-based vascularized tissues for tissue repair and drug screening

Y Wang, RK Kankala, C Ou, A Chen, Z Yang - Bioactive materials, 2022 - Elsevier
The construction of biomimetic vasculatures within the artificial tissue models or organs is
highly required for conveying nutrients, oxygen, and waste products, for improving the …

Microcarriers in application for cartilage tissue engineering: Recent progress and challenges

SL Ding, X Liu, XY Zhao, KT Wang, W Xiong, ZL Gao… - Bioactive Materials, 2022 - Elsevier
Successful regeneration of cartilage tissue at a clinical scale has been a tremendous
challenge in the past decades. Microcarriers (MCs), usually used for cell and drug delivery …

DLP printed hDPSC-loaded GelMA microsphere regenerates dental pulp and repairs spinal cord

Y Qian, J Gong, K Lu, Y Hong, Z Zhu, J Zhang, Y Zou… - Biomaterials, 2023 - Elsevier
Dental pulp regeneration is ideal for irreversible pulp or periapical lesions, and in situ stem
cell therapy is one of the most effective therapies for pulp regeneration. In this study, we …

3D bioprinted vascularized lung cancer organoid models with underlying disease capable of more precise drug evaluation

Y Choi, H Lee, M Ann, M Song, J Rheey, J Jang - Biofabrication, 2023 - iopscience.iop.org
Despite encouraging progress in the development of in vitro cancer models, in vitro cancer
models that simultaneously recapitulate the complexity of the tumor microenvironment and …

New strategy for promoting vascularization in tumor spheroids in a microfluidic assay

Z Wan, MA Floryan, MF Coughlin… - Advanced …, 2023 - Wiley Online Library
Previous studies have developed vascularized tumor spheroid models to demonstrate the
impact of intravascular flow on tumor progression and treatment. However, these models …

Micropore‐forming gelatin methacryloyl (GelMA) bioink toolbox 2.0: Designable tunability and adaptability for 3D bioprinting applications

S Yi, Q Liu, Z Luo, JJ He, HL Ma, W Li, D Wang, C Zhou… - Small, 2022 - Wiley Online Library
It is well‐known that tissue engineering scaffolds that feature highly interconnected and size‐
adjustable micropores are oftentimes desired to promote cellular viability, motility, and …

Hepatocellular carcinoma organoid co-cultures mimic angiocrine crosstalk to generate inflammatory tumor microenvironment

JTC Lim, LG Kwang, NCW Ho, CCM Toh, NSH Too… - Biomaterials, 2022 - Elsevier
Hepatocellular carcinoma (HCC) is the sixth most common cancer and the second leading
cause of cancer worldwide. Despite approvals of several therapeutics to treat advanced …

In Situ Endothelialization of Free‐Form 3D Network of Interconnected Tubular Channels via Interfacial Coacervation by Aqueous‐in‐Aqueous Embedded Bioprinting

S Zhang, C Qi, W Zhang, H Zhou, N Wu… - Advanced …, 2023 - Wiley Online Library
The challenge of bioprinting vascularized tissues is structure retention and in situ
endothelialization. The issue is addressed by adopting an aqueous‐in‐aqueous 3D …

A 3D bioprinted in vitro model of neuroblastoma recapitulates dynamic tumor‐endothelial cell interactions contributing to solid tumor aggressive behavior

L Ning, J Shim, ML Tomov, R Liu, R Mehta… - Advanced …, 2022 - Wiley Online Library
Neuroblastoma (NB) is the most common extracranial tumor in children resulting in
substantial morbidity and mortality. A deeper understanding of the NB tumor …

A comprehensive review on 3D tissue models: Biofabrication technologies and preclinical applications

R Xie, V Pal, Y Yu, X Lu, M Gao, S Liang, M Huang… - Biomaterials, 2023 - Elsevier
The limitations of traditional two-dimensional (2D) cultures and animal testing, when it
comes to precisely foreseeing the toxicity and clinical effectiveness of potential drug …