Cytokine signaling represents one of the cornerstones of the immune system, mediating the
complex responses required to facilitate appropriate immune cell development and function …

Inflammatory responses play pivotal roles in cancer development, including tumor initiation,
promotion, progression, and metastasis. Cytokines are now recognized as important …

The recognition of ω-3 polyunsaturated acids (PUFAs) as essential fatty acids to normal
growth and health was realized more than 80 years ago. However, the awareness of the …

Tumor-associated myeloid cells maintain immunosuppressive microenvironments within
tumors. Identification of myeloid-specific receptors to modulate tumor-associated …

Pancreatic cancer has one of the poorest prognoses of all malignancies, with little
improvement in clinical outcome over the past 40 years. Pancreatic ductal adenocarcinoma …

Abstract Interleukin (IL-) 23 is a central cytokine controlling TH 17 development.
Overshooting IL-23 signaling contribute to autoimmune diseases. Moreover, GWAS studies …

A considerable amount of continuous proliferation and differentiation is required to produce
daily a billion new neutrophils in an adult human. Of the few cytokines and factors known to …

Abstract Interleukin-11 (IL-11) is a member of the glycoprotein-130 (GP-130) cytokines that
utilizes the GP-130 signaling pathway shared by other cytokines of the same family …

Many cytokines are currently under investigation as potential target to improve cardiac
function and outcome in the setting of acute myocardial infarction (MI) or chronic heart failure …

Amylin acts acutely via the area postrema to reduce food intake and body weight, but it also
interacts with leptin over longer periods of time, possibly via the ventromedial hypothalamus …