The Analgesic Properties of Corydalis yanhusuo
Corydalis yanhusuo extract (YHS) has been used for centuries across Asia for pain relief.
The extract is made up of more than 160 compounds and has been identified as alkaloids …
The extract is made up of more than 160 compounds and has been identified as alkaloids …
Molecular mechanism: ERK signaling, drug addiction, and behavioral effects
Addiction to psychostimulants has been considered as a chronic psychiatric disorder
characterized by craving and compulsive drug seeking and use. Over the past two decades …
characterized by craving and compulsive drug seeking and use. Over the past two decades …
Integration of full-length transcriptomics and targeted metabolomics to identify benzylisoquinoline alkaloid biosynthetic genes in Corydalis yanhusuo
D Xu, H Lin, Y Tang, L Huang, J Xu, S Nian… - Horticulture …, 2021 - academic.oup.com
Corydalis yanhusuo WT Wang is a classic herb that is frequently used in traditional Chinese
medicine and is efficacious in promoting blood circulation, enhancing energy, and relieving …
medicine and is efficacious in promoting blood circulation, enhancing energy, and relieving …
Identification and characterization of plant-derived alkaloids, corydine and corydaline, as novel mu opioid receptor agonists
T Kaserer, T Steinacher, R Kainhofer, F Erli, S Sturm… - Scientific reports, 2020 - nature.com
Pain remains a key therapeutic area with intensive efforts directed toward finding effective
and safer analgesics in light of the ongoing opioid crisis. Amongst the neurotransmitter …
and safer analgesics in light of the ongoing opioid crisis. Amongst the neurotransmitter …
Dopamine D1 and D2 receptors mediate analgesic and hypnotic effects of l-tetrahydropalmatine in a mouse neuropathic pain model
YY Liu, TX Wang, JC Zhou, WM Qu, ZL Huang - Psychopharmacology, 2019 - Springer
Rationale Levo-tetrahydropalmatine (l-THP), an active ingredient of Corydalis yanhusuo,
has been reported to be a partial agonist for dopamine D 1 receptors (D 1 R) and an …
has been reported to be a partial agonist for dopamine D 1 receptors (D 1 R) and an …
Microwave-assisted extraction of bioactive alkaloids from Stephania sinica
DT Xie, YQ Wang, Y Kang, QF Hu, NY Su… - Separation and …, 2014 - Elsevier
A microwave-assisted extraction method was developed for the extraction of four bioactive
alkaloids from Stephania sinica, and the quantification of the alkaloids was achieved by …
alkaloids from Stephania sinica, and the quantification of the alkaloids was achieved by …
Levo-tetrahydropalmatine attenuates mouse blood-brain barrier injury induced by focal cerebral ischemia and reperfusion: involvement of Src kinase
XW Mao, CS Pan, P Huang, YY Liu, CS Wang, L Yan… - Scientific reports, 2015 - nature.com
The restoration of blood flow following thrombolytic therapy causes ischemia and
reperfusion (I/R) injury leading to blood-brain barrier (BBB) disruption and subsequent brain …
reperfusion (I/R) injury leading to blood-brain barrier (BBB) disruption and subsequent brain …
Corydaline and l-tetrahydropalmatine attenuate morphine-induced conditioned place preference and the changes in dopamine D2 and GluA1 AMPA receptor …
WN Jiang, X Jing, M Li, H Deng, T Jiang… - European Journal of …, 2020 - Elsevier
Corydalis is a Chinese herb that has been used in China for hundreds of years for analgesic
and other purposes. Corydaline and l-tetrahydropalmatine (l-THP) are the main active …
and other purposes. Corydaline and l-tetrahydropalmatine (l-THP) are the main active …
Morphine Withdrawal-Induced Hyperalgesia in Models of Acute and Extended Withdrawal Is Attenuated by l-Tetrahydropalmatine
D Oleinichenko, S Ahn, R Song, TP Snutch… - International Journal of …, 2023 - mdpi.com
Effective pain control is an underappreciated aspect of managing opioid withdrawal, and its
absence presents a significant barrier to successful opioid detoxification. Accordingly, there …
absence presents a significant barrier to successful opioid detoxification. Accordingly, there …
Levo-tetrahydropalmatine attenuates the development and expression of methamphetamine-induced locomotor sensitization and the accompanying activation of ERK …
N Zhao, Y Chen, J Zhu, L Wang, G Cao, Y Dang, C Yan… - Neuroscience, 2014 - Elsevier
Abstract Levo-tetrahydropalmatine (l-THP) is an alkaloid purified from corydalis and has
been used in many traditional Chinese herbal preparations for its analgesic, sedative, and …
been used in many traditional Chinese herbal preparations for its analgesic, sedative, and …