Mammalian models including non‐human primates, pigs and rodents have been used
extensively to study the mechanisms of cardiovascular disease. However, there is an …

Atherosclerotic cardiovascular disease is a major cause of death among humans. Animal
models have shown that cholesterol and inflammation are causatively involved in the …

Lipid nanoparticles (LNPs) are the leading nonviral technologies for the delivery of
exogenous RNA to target cells in vivo. As systemic delivery platforms, these technologies …

The interactions of nanomedicines with biological environments is heavily influenced by
their physicochemical properties. Formulation design and optimization are therefore key …

Perfluorooctanoic acid (PFOA), a typical perfluoroalkyl group compound, has received
worldwide attention due to its significant environmental toxicity. Following regulatory bans …

Coronary artery disease (CAD) is the leading form of cardiovascular disease (CVD), which is
the primary cause of mortality worldwide. It is a complex disease with genetic and …

Endothelial cells display an extraordinary plasticity both during development and throughout
adult life. During early development, endothelial cells assume arterial, venous, or lymphatic …

The low-density lipoprotein receptor (LDLR) controls cellular delivery of cholesterol and
clears LDL from the bloodstream, protecting against atherosclerotic heart disease, the …

Cytoplasmic lipid droplets are highly dynamic storage organelles that are critical for cellular
lipid homeostasis. While the molecular details of lipid droplet dynamics are a very active …

Messenger RNA (mRNA) has emerged as a novel therapeutic approach for inborn errors of
metabolism. Classic galactosemia (CG) is an inborn error of galactose metabolism caused …