Transforming growth factor-β-induced protein (TGFBIp), an extracellular matrix protein, is the
second most abundant protein in the corneal stroma. In this review, we summarize the …

Glycosaminoglycans (GAGs) are long and unbranched polysaccharides that are abundant
in the extracellular matrix and basement membrane of multicellular organisms. These linear …

Lactotropes are prolactin (PRL)-secreting endocrine cells in the anterior pituitary. We have
established the zinc finger protein ZBTB20 as an essential transcription factor for lactotrope …

Amyloids are highly organized cross β-sheet protein nanofibrils that are associated with both
diseases and functions. Thermodynamically amyloids are stable structures as they represent …

Vasoinhibin is an endogenous prolactin (PRL) fragment with profibrinolytic,
antivasopermeability, and antiangiogenic effects. The fact that blood clotting, vascular …

Numerous pathophysiological conditions are associated with the misfolding and
aggregation of proteins into insoluble amyloid fibrils. The mechanisms by which this process …

Vasoinhibin belongs to a family of angiogenesis inhibitors generated when the fourth α-helix
(H4) of the hormone prolactin (PRL) is removed by specific proteolytic cleavage. The …

Zinc is the second most abundant transition metal in humans and an essential nutrient
required for growth and development of newborns. During lactation, mammary epithelial …

A phosphorylated prolactin is a kind of modified prolactin, which is produced through
phosphorylation of native prolactin (PRL) by p21-activated kinase 2 (PAK2) in secretory …

Babies are born to breastfeed. While 50% of lactating persons struggle to make enough
milk, there are no governmentally-approved drugs to enhance lactation. This dissertation the …