Metal elements represent some of the most fundamental chemical building blocks of life and
are required to sustain the growth, development, and sustenance of all living organisms and …

Colorectal cancer (CRC), despite numerous therapeutic and screening attempts, still
remains a major life-threatening malignancy. CRC etiology entails both genetic and …

Thyroid cancer is the most common endocrine cancer. There is no systematic screening for
such cancer, and the current challenge is to find potential biomarkers to facilitate an early …

As a component of many minerals and an essential trace element in most aerobic
organisms, the transition metal element Cu is important for studying reduction-oxidation …

As a consequence of recent developments in mass spectrometry, the application of non-
traditional stable isotope systems (eg Ca, Cu, Fe, Mg, Sr, Zn) as well as radiogenic isotopes …

All elements with two or more isotopes show natural variation in their isotopic composition
as a result of the isotope fractionation that accompanies (bio) chemical reactions and (bio) …

Wilson disease (WD) is an autosomal recessive disorder of copper (Cu) metabolism. The
gene responsible for WD, ATP7B, is involved in the cellular transport of Cu, and mutations in …

Zinc (Zn) accumulates in breast cancer tumors compared to adjacent healthy tissue. Clinical
samples display isotopic compositions (delta-66Zn) of Zn in breast cancer tissue that are …

Patients with chronic liver disease from different aetiologies show a light serum Cu isotopic
composition compared to the reference population, with the enrichment in the 63Cu isotope …

Metallomics is a rapidly evolving field of bio-metal research that integrates techniques and
perspectives from other “-omics” sciences (eg genomics, proteomics) and from research …