Nanocarriers have therapeutic potential to facilitate drug delivery, including biological
agents, small-molecule drugs, and nucleic acids. However, their efficiency is limited by …

Defects in the genome cause genetic diseases and can be treated with gene therapy. Due to
the limitations encountered in gene delivery, lipid-based supramolecular colloidal materials …

Cryptotanshinone (CTS) is a promising therapeutic option for pulmonary fibrosis (PF).
However, clinical applications of CTS are limited owing to high photosensitivity and poor …

Antisense oligonucleotides (ASOs) usually contain a fully phosphorothioate (PS) backbone,
which possibly interact with many genes and proteins under intracellular conditions. G3139 …

Lipid derivatives of nucleoside analogs have been highlighted for their potential for effective
gene delivery. A novel class of nucleobase-lipids are rationally designed and readily …

Small interfering RNAs (siRNAs) are widely studied for their highly specific gene silencing
activity. However, obstacles remain to the clinical application of siRNAs. Attaching …

The development of effective anti-cancer therapeutics remains one of the current
pharmaceutical challenges. The joint delivery of chemotherapeutic agents and …

The cyclic Arg-Gly-Asp (cRGD) peptides are widely used as tumor-targeting ligands due to
their specific binding ability to integrin αvβ3, which is overexpressed on the surface of …

The mutant BRAF gene is widely expressed in melanoma, and it acts as a suitable antitumor
target. Small interference RNA (siRNA)-based therapy for BRAF V600E mRNA is, therefore …

With the rapid development of synthetic technology and biological technology, many nucleic
acid‐based drugs have entered the clinical trials. However, their inherent disabilities in …