Synthetic glycans to improve current glycoconjugate vaccines and fight antimicrobial resistance

L Del Bino, KE Østerlid, DY Wu, F Nonne… - Chemical …, 2022 - ACS Publications
Antimicrobial resistance (AMR) is emerging as the next potential pandemic. Different
microorganisms, including the bacteria Acinetobacter baumannii, Clostridioides difficile …

Mechanisms of antibiotic resistance in enterococci

WR Miller, JM Munita, CA Arias - Expert review of anti-infective …, 2014 - Taylor & Francis
Multidrug-resistant (MDR) enterococci are important nosocomial pathogens and a growing
clinical challenge. These organisms have developed resistance to virtually all antimicrobials …

The rise of the Enterococcus: beyond vancomycin resistance

CA Arias, BE Murray - Nature Reviews Microbiology, 2012 - nature.com
The genus Enterococcus includes some of the most important nosocomial multidrug-
resistant organisms, and these pathogens usually affect patients who are debilitated by …

Envelope structures of Gram-positive bacteria

M Rajagopal, S Walker - Protein and sugar export and assembly in Gram …, 2017 - Springer
Gram-positive organisms, including the pathogens Staphylococcus aureus, Streptococcus
pneumoniae, and Enterococcus faecalis, have dynamic cell envelopes that mediate …

Lipoteichoic acid synthesis and function in gram-positive bacteria

MG Percy, A Gründling - Annual review of microbiology, 2014 - annualreviews.org
Lipoteichoic acid (LTA) is an important cell wall polymer found in gram-positive bacteria.
Although the exact role of LTA is unknown, mutants display significant growth and …

Teichoic acids and related cell-wall glycopolymers in Gram-positive physiology and host interactions

C Weidenmaier, A Peschel - Nature Reviews Microbiology, 2008 - nature.com
Abstract Abstract| Most Gram-positive bacteria incorporate membrane-or peptidoglycan-
attached carbohydrate-based polymers into their cell envelopes. Such cell-wall …

Potential targets for next generation antimicrobial glycoconjugate vaccines

F Micoli, P Costantino, R Adamo - FEMS microbiology reviews, 2018 - academic.oup.com
Cell surface carbohydrates have been proven optimal targets for vaccine development.
Conjugation of polysaccharides to a carrier protein triggers a T-cell-dependent immune …

Comparative genomics of enterococci: variation in Enterococcus faecalis, clade structure in E. faecium, and defining characteristics of E. gallinarum and E …

KL Palmer, P Godfrey, A Griggs, VN Kos, J Zucker… - MBio, 2012 - Am Soc Microbiol
The enterococci are Gram-positive lactic acid bacteria that inhabit the gastrointestinal tracts
of diverse hosts. However, Enterococcus faecium and E. faecalis have emerged as leading …

[HTML][HTML] Pathogenesis and immunity in enterococcal infections

IG Sava, E Heikens, J Huebner - Clinical microbiology and infection, 2010 - Elsevier
Enterococcus faecalis and Enterococcus faecium have emerged as multi-resistant
nosocomial pathogens in immunocompromised and critically ill patients. Multi-resistant …

Capsular Polysaccharide Production in Enterococcus faecalis and Contribution of CpsF to Capsule Serospecificity

LR Thurlow, VC Thomas, LE Hancock - Journal of bacteriology, 2009 - Am Soc Microbiol
Many bacterial species produce capsular polysaccharides that contribute to pathogenesis
through evasion of the host innate immune system. The gram-positive pathogen …