Obesity is a major risk factor for the development of insulin resistance and type 2 diabetes.
The exact mechanism by which adipose tissue induces insulin resistance is still unclear. It …

Background Polycystic ovarian syndrome (PCOS) is the most prevalent metabolic disorder
in reproductive-age women. It is indeed a multifactorial condition evidenced by ovarian …

Polycystic ovary syndrome (PCOS) is the most common hormonal imbalance disease in
reproductive‐aged women. Its basic characteristics are ovulatory dysfunction and ovarian …

Highly ordered interactions between immune and metabolic responses are evolutionarily
conserved and paramount for tissue and organismal health. Disruption of these interactions …

Low-grade tissue inflammation induced by obesity can result in insulin resistance, which in
turn is a key cause of type 2 diabetes mellitus. Cells of the innate immune system produce …

Chronic, low-grade adipose tissue inflammation is a key etiological mechanism linking the
increasing incidence of type 2 diabetes (T2D) and obesity. It is well recognized that the …

It is now recognized that obesity is driving the type 2 diabetes epidemic in Western
countries. Obesity-associated chronic tissue inflammation is a key contributing factor to type …

A strong grounding in basic histology is essential for all pathologists. However, there had
always been a gap between histology and pathology in which histologic information …

Tumor necrosis factor-α (TNF-α) has been shown to have certain catabolic effects on fat cells
and whole animals. An induction of TNF-α messenger RNA expression was observed in …

Methods for assessment, eg., anthropometric indicators and imaging techniques, of several
phenotypes of human obesity, with special reference to abdominal fat content, have been …