Future directions in the treatment of osteosarcoma : Current Opinion in Pediatrics Future
directions in the treatment of osteosarcoma : Current Opinion in Pediatrics Log in or Register …

Osteosarcoma is a disease with many complex genetic abnormalities but few well defined
genetic drivers of tumor initiation and evolution. The disease is diagnosed and defined …

In vitro modeling of human disease has recently become feasible with induced pluripotent
stem cell (iPSC) technology. Here, we established patient-derived iPSCs from a Li-Fraumeni …

Background: Osteosarcoma (OS) is the most common primary bone tumor. The disease has
a poor prognosis due to the delay in the diagnosis and the development of metastasis. N6 …

Aberrant methylation of genomic DNA has been reported in many cancers. Specific DNA
methylation patterns have been shown to provide clinically useful prognostic information …

Micro ribonucleic acids (miRNAs) are small non-coding RNA segments that have a role in
the regulation of normal cellular development and proliferation including normal …

Background Osteosarcoma is a rare malignant bone tumor in adolescents and children.
Poor prognosis has always been a difficult problem for patients with osteosarcoma. Recent …

Osteosarcoma (OS) is the most common cancer of bone and the 5th leading cause of cancer-
related death in young adults. Currently, 5-year survival rates have plateaued at~ 70% for …

Background Despite the comparatively low prevalence of osteosarcoma (OS) compared to
other cancer types, metastatic OS has a poor overall survival rate of fewer than 30 …

Osteosarcoma is the most common type of malignant bone cancer, which often affects
teenagers and young adults. The present study aimed to screen for critical genes and …