Microtubules have fundamental roles in many essential biological processes, including cell
division and intracellular transport. They assemble and disassemble from their two ends …

The molecular mechanisms by which microtubule-associated proteins (MAPs) regulate the
dynamic properties of microtubules (MTs) are still poorly understood. We review recent …

Proteomics has revealed that the~ 20,000 human genes engender a far greater number of
proteins, or proteoforms, that are diversified in large part by post-translational modifications …

Microtubules are hollow tubes essential for many cellular functions such as cell polarization
and migration, intracellular trafficking and cell division. They are polarized polymers …

Mechanisms controlling microtubule dynamics at the cell cortex play a crucial role in cell
morphogenesis and neuronal development. Here, we identified kinesin-4 KIF21A as an …

The regulation of microtubule dynamics is critical to ensure essential cell functions, such as
proper segregation of chromosomes during mitosis or cell polarity and migration. End …

In cells, a complex network of proteins regulates the dynamic growth of microtubules that is
essential for division and migration. In vitro approaches with purified components have so …

+ TIPs are a heterogeneous class of proteins that specifically bind to growing microtubule
ends. Because dynamic microtubules are essential for many intracellular processes,+ TIPs …

Regulation of the microtubule cytoskeleton is of pivotal importance for neuronal
development and function. One such regulatory mechanism centers on microtubule plus …

End-binding proteins (EBs) are adaptors that recruit functionally diverse microtubule plus-
end-tracking proteins (+ TIPs) to growing microtubule plus ends. To test with high spatial and …