Prions are unusual protein assemblies that propagate their conformationally-encoded
information in absence of nucleic acids. The first prion identified, the scrapie isoform (PrPSc) …

The term “prion disease” encompasses a group of neurodegenerative diseases affecting
both humans and animals. Currently, there is no effective therapy and all forms of prion …

Highlights•Cell-free prion replication assays promise to speed up the drug discovery
process.•Astrocytes derived from human iPS cells are susceptible to human prions.•Prion …

Posttranslational modifications (PTMs) are common among proteins that aggregate in
neurodegenerative disease, yet how PTMs impact the aggregate conformation and disease …

The resolution of the three-dimensional structure of infectious prions at the atomic level is
pivotal to understand the pathobiology of Transmissible Spongiform Encephalopathies …

Understanding the structure of PrPSc is without doubt a sine qua non to understand not only
PrPSc propagation, but also critical features of that process such as the strain phenomenon …

Deformed templating is the process by which self-replicating protein conformations with a
given cross-β folding pattern can seed formation of an alternative self-replicating state with …

Although prions are known as protein-only infectious particles, they exhibit lipid specificities,
cofactor dependencies and membrane-dependent activities. Such membrane interactions …

Transmissible spongiform encephalopathies, also known as prion diseases, are a group of
fatal neurodegenerative disorders affecting both humans and animals. The central …

We investigated the extent to which contact with mineral surfaces affected the molecular
integrity of a model protein, with an emphasis on identifying the mechanisms (hydrolysis …