Lipid droplet functions beyond energy storage

MA Welte, AP Gould - Biochimica et Biophysica Acta (BBA)-Molecular and …, 2017 - Elsevier
Lipid droplets are cytoplasmic organelles that store neutral lipids and are critically important
for energy metabolism. Their function in energy storage is firmly established and …

Lipid droplets and cellular lipid metabolism

TC Walther, RV Farese Jr - Annual review of biochemistry, 2012 - annualreviews.org
Among organelles, lipid droplets (LDs) uniquely constitute a hydrophobic phase in the
aqueous environment of the cytosol. Their hydrophobic core of neutral lipids stores …

Bidirectional cargo transport: moving beyond tug of war

WO Hancock - Nature reviews Molecular cell biology, 2014 - nature.com
Vesicles, organelles and other intracellular cargo are transported by kinesin and dynein
motors, which move in opposite directions along microtubules. This bidirectional cargo …

Insect fat body: energy, metabolism, and regulation

EL Arrese, JL Soulages - Annual review of entomology, 2010 - annualreviews.org
The fat body plays major roles in the life of insects. It is a dynamic tissue involved in multiple
metabolic functions. One of these functions is to store and release energy in response to the …

In vitro reconstitution of a highly processive recombinant human dynein complex

MA Schlager, HT Hoang, L Urnavicius… - The EMBO …, 2014 - embopress.org
Cytoplasmic dynein is an approximately 1.4 MDa multi‐protein complex that transports many
cellular cargoes towards the minus ends of microtubules. Several in vitro studies of …

Coupling of the nucleus and cytoplasm: role of the LINC complex

M Crisp, Q Liu, K Roux, JB Rattner… - The Journal of cell …, 2006 - rupress.org
The nuclear envelope defines the barrier between the nucleus and cytoplasm and features
inner and outer membranes separated by a perinuclear space (PNS). The inner nuclear …

Manipulation and motion of organelles and single molecules in living cells

K Norregaard, R Metzler, CM Ritter… - Chemical …, 2017 - ACS Publications
The biomolecule is among the most important building blocks of biological systems, and a
full understanding of its function forms the scaffold for describing the mechanisms of higher …

The biogenesis and functions of lipid bodies in animals, plants and microorganisms

DJ Murphy - Progress in lipid research, 2001 - Elsevier
What are lipid bodies? One of the problems in answering this apparently simple question is
that these macromolecular proteolipid assemblies can be relatively heterogeneous with …

PAT proteins, an ancient family of lipid droplet proteins that regulate cellular lipid stores

PE Bickel, JT Tansey, MA Welte - … et Biophysica Acta (BBA)-Molecular and …, 2009 - Elsevier
The PAT family of lipid droplet proteins includes 5 members in mammals: perilipin, adipose
differentiation-related protein (ADRP), tail-interacting protein of 47 kDa (TIP47), S3–12, and …

History of optical trapping and manipulation of small-neutral particle, atoms, and molecules

A Ashkin - IEEE Journal of Selected Topics in Quantum …, 2000 - ieeexplore.ieee.org
Reviews the history of optical trapping and manipulation of small-neutral particles, from the
time of its origin in 1970 up to the present. As we shall see, the unique characteristics of this …