Background In the past decade, Lynn Etheredge presented a vision for the Learning Health
System (LHS) as an opportunity for increasing the value of health care via rapid learning …

Impact This is an introduction to an article series devoted to the current state and future of
pediatric research. The role of public–private partnerships, influencing factors, challenges …

A learning health system (LHS) integrates research done in routine care settings, structured
data capture during every encounter, and quality improvement processes to rapidly …

Except for a few conditions, pediatric disorders are rare diseases. Because of this, no single
institution has enough patients to generate adequate sample sizes to produce generalizable …

BACKGROUND: The caudal block is the most commonly performed regional anesthesia
technique in pediatric patients undergoing surgical procedures, but safety concerns raised …

Introduction The US health care system faces pressure to improve quality while managing
complexity, curbing costs, and reducing inefficiency. These shortcomings have sparked …

To establish a foundation for methodologically sound research on the epidemiology,
assessment, and treatment of pediatric feeding disorder (PFD), a 28-member …

Improving standards of living have resulted in an increased focus on health and image
management. In a context where the quality of healthcare information is unguaranteed, the …

Drug therapy is a powerful tool to improve outcome, but there is an urgent need to improve
pharmacotherapy in neonates through tailored prevention and management of adverse drug …

The main goal of the NIH/NCATS GRDR® program is to serve as a central web-based
global data repository to integrate de-identified patient clinical data from rare disease …