Lung transplantation (LTx) can be a life-extending treatment option for patients with
advanced and/or progressive fibrotic interstitial lung disease (ILD), especially idiopathic …

In patients with systemic sclerosis (SSc), gastrointestinal (GI)-tract involvement is almost
universal. Any segment of the GI tract from mouth to anus can be involved, and GI symptoms …

Background The relationship between gastroesophageal reflux disease (GERD) and
idiopathic pulmonary fibrosis (IPF) is controversial. Current guidelines recommend that …

Gastrointestinal dysmotility in systemic sclerosis (scleroderma) is prevalent in 90% of
patients, increasing morbidity and in some cases mortality. The resultant gastrointestinal …

Progressive systemic sclerosis (PSS) causes smooth muscle atrophy and fibrosis of the
distal two-thirds of the esophagus. Motility studies show reduced-amplitude or absent …

OBJECTIVES: Interstitial lung disease (ILD) is currently the main cause of death in systemic
sclerosis (SSc) and has an unknown pathogenesis. Gastroesophageal reflux (GER) has …

Nearly all patients with systemic sclerosis (SSc) are negatively affected by dysfunction in the
gastrointestinal tract, and the severity of gastrointestinal disease in SSc correlates with high …

Leakage from the esophagus and gastroesophageal junction can be lethal due to
uncontrolled contamination of the mediastinum. The most predominant risk factors for the …

Systemic sclerosis is a chronic disorder of connective tissue that affects the gastrointestinal
tract in more than 80% of patients. Changes in neuromuscular function with progressive …

Considered to be the definitive reference work, this fourth edition has been extensively
reviewed. As a result, the size and content of various sections have been modified and new …