Self-microemulsifying drug delivery system (SMEDDS)–challenges and road ahead

S Dokania, AK Joshi - Drug delivery, 2015 - Taylor & Francis
Self-microemulsifying drug delivery system (SMEDDS) has emerged as a vital strategy to
formulate poor water soluble compounds for bioavailability enhancement. However, certain …

Developments of Polysorbate (Tween) based microemulsions: Preclinical drug delivery, toxicity and antimicrobial applications

G Kaur, SK Mehta - International journal of pharmaceutics, 2017 - Elsevier
The present review deals with the progress of Polysorbates (Tween) based microemulsions
in drug delivery. PEGylated Sorbitan Fatty Acid Esters (Tweens/Polysorbates) are one of the …

Novel solid self-nanoemulsifying drug delivery system (S-SNEDDS) for oral delivery of olmesartan medoxomil: design, formulation, pharmacokinetic and …

A Nasr, A Gardouh, M Ghorab - Pharmaceutics, 2016 - mdpi.com
The main purpose of this study was to develop a solid self-nanoemulsifying drug delivery
system (S-SNEDDS) of Olmesartan (OLM) for enhancement of its solubility and dissolution …

Lipid-based nanoparticles for drug-delivery systems

R Kumar - Nanocarriers for drug delivery, 2019 - Elsevier
The discovery of new drug molecules depends on a number of steps, which limits the
development of feasible new drugs for the treatment of disease without any side effects …

Nanoemulsion improves the oral absorption of candesartan cilexetil in rats: performance and mechanism

F Gao, Z Zhang, H Bu, Y Huang, Z Gao, J Shen… - Journal of controlled …, 2011 - Elsevier
Candesartan cilexetil (CC), an inactive prodrug of candesartan, was rapidly hydrolyzed into
active candesartan during absorption in the gastrointestinal (GI) tract to achieve …

Transforming lipid-based oral drug delivery systems into solid dosage forms: an overview of solid carriers, physicochemical properties, and biopharmaceutical …

A Tan, S Rao, CA Prestidge - Pharmaceutical research, 2013 - Springer
The diversity of lipid excipients available commercially has enabled versatile formulation
design of lipid-based drug delivery systems for enhancing the oral absorption of poorly …

Solid lipid nanoparticles loading candesartan cilexetil enhance oral bioavailability: in vitro characteristics and absorption mechanism in rats

Z Zhang, F Gao, H Bu, J Xiao, Y Li - … : Nanotechnology, Biology and …, 2012 - Elsevier
Candesartan cilexetil (CC) is widely used for the treatment of hypertension and heart failure,
but it shows very poor aqueous solubility and very low oral absorption. In this work, CC …

Colloidal aspects of dispersion and digestion of self-dispersing lipid-based formulations for poorly water-soluble drugs

K Vithani, V Jannin, CW Pouton, BJ Boyd - Advanced drug delivery reviews, 2019 - Elsevier
Self-dispersing lipid-based formulations, particularly self-microemulsifying drug delivery
systems (SMEDDS) have gained an increased interest in recent times as a means to …

Self-emulsifying granules and pellets: Composition and formation mechanisms for instant or controlled release

I Nikolakakis, I Partheniadis - Pharmaceutics, 2017 - mdpi.com
Many articles have been published in the last two decades demonstrating improvement in
the dissolution and absorption of low solubility drugs when formulated into self-emulsifying …

Production, properties, and applications of solid self-emulsifying delivery systems (S-SEDS) in the food and pharmaceutical industries

A Gonçalves, N Nikmaram, S Roohinejad… - Colloids and Surfaces A …, 2018 - Elsevier
The food and pharmaceutical industries aim to develop innovative delivery systems to meet
the increasing consumer demand for healthier and safer food products and to improve the …