Secretory epithelial cells of the proximal airways synthesize and secrete gel-forming
polymeric mucins. The secreted mucins adsorb water to form mucus that is propelled by …

SNARE-complexes drive the fusion of membrane-bound vesicles with target membranes or
with each other (homotypic fusion). The SNARE-proteins are subdivided into Q a, Q b, Q c …

It is now known that proteins associated with neurodegenerative disease can spread
throughout the brain in a prionlike manner. However, the mechanisms regulating the trans …

Upon activation by extracellular matrix components or soluble agonists, platelets release in
excess of 300 active molecules from intracellular granules. Those factors can both activate …

Cell navigation is the process whereby cells or cytoplasmic extensions are guided from one
point to another in multicellular organisms or, in the case of unicellular eukaryotic …

Neuronal dense-core vesicles (DCVs) transport and secrete neuropeptides necessary for
development, plasticity and survival, but little is known about their fusion mechanism. We …

The establishment and maintenance of pregnancy in humans proceed through a continuous
change of biochemical and biophysical processes. It requires a constant interaction between …

• Introduction• SNARE function in membrane fusion events• Expression of SNAREs and
SNARE complexes in mast cells• Functional studies implicating specific SNAREs or SNARE …

SNARE-mediated membrane fusion plays a crucial role in presynaptic vesicle exocytosis
and also in postsynaptic receptor delivery. The latter is considered particularly important for …

Airway mucin secretion is important pathophysiologically and as a model of polarized
epithelial regulated exocytosis. We find the trafficking protein, SNAP23 (23-kDa paralogue of …