Learning Objectives After completing this course, the reader will be able to: Discuss the
basic principles of molecular and cellular biology of LGL leukemia. Describe distinct clinical …

Thrombocytopenia is a frequent complication of cancer and its treatment. The causes of
thrombocytopenia in cancer patients can be diverse and multifactorial. Systemic …

T cell large granular lymphocyte (T-LGL) leukemia features a clonal expansion of antigen-
primed, competent, cytotoxic T lymphocytes (CTL). To systematically understand signaling …

Foxp3+ regulatory T cells (Tregs) play a central role in maintaining immune tolerance. A
reduction in the function of Tregs is a key feature of autoimmune diseases, whereas their …

The role of CD4+ T cells in the pathogenesis of aplastic anemia (AA) is not well
characterized. We investigate CD4+ T-cell subsets in AA. Sixty-three patients with acquired …

Immunological responses are increasingly recognised as being important in the initiation
and progression of myelodysplastic syndrome (MDS). Indeed, autoimmune diseases …

Familial myelodysplastic syndromes arise from haploinsufficiency of genes involved in
hematopoiesis and are primarily associated with early-onset disease. Here we describe a …

Abstract JAK2 V617F mutation recently was identified as a pathogenic factor in typical
chronic myeloproliferative diseases (CMPD). Some forms of myelodysplastic syndromes …

Cutaneous T‐cell lymphomas (CTCL) are a heterogeneous group of malignancies derived
from skin‐homing T cells. The most common forms of CTCL are Mycosis Fungoides (MF) …

T-cell large granular lymphocytic leukemia and chronic lymphoproliferative disorder of
natural killer cells are intriguing entities between benign and malignant lymphoproliferation …