Lung cancer is the deadliest malignancy worldwide. An inflammatory microenvironment is a
key factor contributing to lung tumor progression. Tumor-Associated Macrophages (TAMs) …

Chemokines are small molecules called “chemotactic cytokines” and regulate many
processes like leukocyte trafficking, homing of immune cells, maturation, cytoskeletal …

Tumor-associated macrophages (TAMs) play an important role in regulating tumor growth,
invasion and metastasis, and constitute approximately 50% of tumor mass. TAMs can exist …

Abstract AMD3100 (plerixafor), a CXCR4 antagonist, has opened a variety of avenues for
potential therapeutic approaches in different refractory diseases. The CXCL12/CXCR4 axis …

Lung cancer persists to contribute to one-quarter of cancer-associated deaths. Among the
different histologies, non-small cell lung cancer (NSCLC) alone accounts for 85% of the …

Cancer stem cells (CSCs) are a subset of highly tumorigenic cells in tumors. They have
enhanced self-renewal properties, are usually chemo-radioresistant, and can promote tumor …

Abstract Background Siglec-15 (S15) is a type-I transmembrane protein and is considered a
new candidate of immune checkpoint inhibitor for cancer immunotherapy. Methods In the …

Lung cancer is the leading cause of cancer-related death worldwide. Bone metastasis,
which usually accompanies severe skeletal-related events, is the most common site for …

Globally, cancer is growing more prevalent and affects the great majority of people; as a
result, new anticancer medications are presently being developed, and their safety is …

Abstract Development of a single combinatorial nanoplatform technology to target cancer
cells has been an unprecedented reality in boosting synergistic antitumor activities and in …