Infections at the maternal–fetal interface: an overview of pathogenesis and defence

CJ Megli, CB Coyne - Nature Reviews Microbiology, 2022 - nature.com
Infections are a major threat to human reproductive health, and infections in pregnancy can
cause prematurity or stillbirth, or can be vertically transmitted to the fetus leading to …

Pathogens and the placental fortress

JR Robbins, AI Bakardjiev - Current opinion in microbiology, 2012 - Elsevier
Placental infections are major causes of maternal and fetal disease. This review introduces
a new paradigm for placental infections based on current knowledge of placental defenses …

Placental syncytium forms a biophysical barrier against pathogen invasion

VB Zeldovich, CH Clausen, E Bradford… - PLoS …, 2013 - journals.plos.org
Fetal syncytiotrophoblasts form a unique fused multinuclear surface that is bathed in
maternal blood, and constitutes the main interface between fetus and mother …

Challenges and perspectives of Chagas disease: a review

PCM Pereira, EC Navarro - Journal of venomous animals and toxins …, 2013 - SciELO Brasil
Chagas disease (CD), also known as American trypanosomiasis, is caused by the
flagellated protozoan Trypanosoma cruzi, and affects an estimated 8 to 10 million people …

Congenital Transmission of Trypanosoma cruzi: A Review About the Interactions Between the Parasite, the Placenta, the Maternal and the Fetal/Neonatal Immune …

U Kemmerling, A Osuna, AG Schijman… - Frontiers in …, 2019 - frontiersin.org
Chagas disease (CD), caused by the protozoan parasite Trypanosoma cruzi, is considered
a neglected tropical disease by the World Health Organization. Congenital transmission of …

A local innate immune response against Trypanosoma cruzi in the human placenta: the epithelial turnover of the trophoblast

A Liempi, C Castillo, I Carrillo, L Muñoz, D Droguett… - Microbial …, 2016 - Elsevier
Congenital Chagas disease, caused by Trypanosoma cruzi, is partially responsible for the
progressive globalization of Chagas disease despite of its low transmission rate. The …

Natural sesquiterpene lactones induce programmed cell death in Trypanosoma cruzi: a new therapeutic target?

V Jimenez, U Kemmerling, R Paredes, JD Maya… - Phytomedicine, 2014 - Elsevier
Abstract Background Chagas disease or American Trypanosomiasis is caused by the
flagellated protozoan parasite Trypanosoma cruzi (T. cruzi) and is recognized by the WHO …

Trypanosoma cruzi, Chagas disease and cancer: putting together the pieces of a complex puzzle

CD Kaufman, C Farré, L Biscari, AR Pérez… - Frontiers in Cell and …, 2023 - frontiersin.org
Considering the extensive and widespread impact on individuals, cancer can presently be
categorized as a pandemic. In many instances, the development of tumors has been linked …

Pathophysiology of Leishmania infection during pregnancy

BA Berger, AH Bartlett, NG Saravia, NG Sevilla - Trends in parasitology, 2017 - cell.com
The pathological processes resulting from parasitic infection are known to have important
impacts on the mother child dyad during pregnancy. The roles of parasite transmission and …

Modeling the ruminant placenta-pathogen interactions in apicomplexan parasites: current and future perspectives

I Pastor-Fernández, E Collantes-Fernández… - Frontiers in Veterinary …, 2021 - frontiersin.org
Neospora caninum and Toxoplasma gondii are one of the main concerns of the livestock
sector as they cause important economic losses in ruminants due to the reproductive failure …