Stem cells perform many different functions, each of which requires specific metabolic
adaptations. Over the past decades, studies of pluripotent and tissue stem cells have …

Pluripotent cells emerge as a naive founder population in the blastocyst, acquire capacity for
germline and soma formation, and then undergo lineage priming. Mouse embryonic stem …

Pluripotent stem cells give rise to all cells of the adult organism, making them an invaluable
tool in regenerative medicine. In response to differentiation cues, they can activate markedly …

Cell fate transitions are frequently accompanied by changes in cell shape and mechanics.
However, how cellular mechanics affects the instructive signaling pathways controlling cell …

Cell differentiation typically occurs with concomitant shape transitions to enable specialized
functions. To adopt a different shape, cells need to change the mechanical properties of their …

Despite four decades of effort, robust propagation of pluripotent stem cells from livestock
animals remains challenging. The requirements for self-renewal are unclear and the …

Stem cells are a hallmark of animal multicellularity. Sox and POU transcription factors are
associated with stemness and were believed to be animal innovations, reported absent in …

In contrast to conventional human pluripotent stem cells (hPSCs) that are related to post-
implantation embryo stages, naive hPSCs exhibit features of pre-implantation epiblast …

At implantation, the embryo establishes contacts with the maternal endometrium. This stage
is associated with a high incidence of preclinical pregnancy losses. While the maternal …

Primordial germ cells (PGCs) are the early embryonic precursors of gametes–sperm and
egg cells. PGC-like cells (PGCLCs) can currently be derived in vitro from pluripotent cells …