Amyloid oligomers: A joint experimental/computational perspective on Alzheimer's disease, Parkinson's disease, type II diabetes, and amyotrophic lateral sclerosis

PH Nguyen, A Ramamoorthy, BR Sahoo… - Chemical …, 2021 - ACS Publications
Protein misfolding and aggregation is observed in many amyloidogenic diseases affecting
either the central nervous system or a variety of peripheral tissues. Structural and dynamic …

Neuroinflammation as a common feature of neurodegenerative disorders

L Guzman-Martinez, RB Maccioni, V Andrade… - Frontiers in …, 2019 - frontiersin.org
Neurodegenerative diseases share the fact that they derive from altered proteins that
undergo an unfolding process followed by formation of β-structures and a pathological …

Glycogen synthase kinase-3 (GSK3): regulation, actions, and diseases

E Beurel, SF Grieco, RS Jope - Pharmacology & therapeutics, 2015 - Elsevier
Abstract Glycogen synthase kinase-3 (GSK3) may be the busiest kinase in most cells, with
over 100 known substrates to deal with. How does GSK3 maintain control to selectively …

Autophagy induction as a therapeutic strategy for neurodegenerative diseases

A Djajadikerta, S Keshri, M Pavel, R Prestil… - Journal of molecular …, 2020 - Elsevier
Autophagy is a major, conserved cellular pathway by which cells deliver cytoplasmic
contents to lysosomes for degradation. Genetic studies have revealed extensive links …

α-synuclein in the pathophysiology of Alzheimer's disease

D Twohig, HM Nielsen - Molecular neurodegeneration, 2019 - Springer
The Alzheimer's disease (AD) afflicted brain is neuropathologically defined by extracellular
amyloid-β (Aβ) plaques and intraneuronal neurofibrillary tangles composed of …

Tau protein interaction partners and their roles in Alzheimer's disease and other tauopathies

J Sinsky, K Pichlerova, J Hanes - International journal of molecular …, 2021 - mdpi.com
Tau protein plays a critical role in the assembly, stabilization, and modulation of
microtubules, which are important for the normal function of neurons and the brain. In …

Shaping the Nrf2-ARE-related pathways in Alzheimer's and Parkinson's diseases

L Fão, SI Mota, AC Rego - Ageing Research Reviews, 2019 - Elsevier
A failure in redox homeostasis is a common hallmark of Alzheimer's Disease (AD) and
Parkinson's Disease (PD), two age-dependent neurodegenerative disorders (NDD), causing …

Pleiotropic effects of GLP-1 and analogs on cell signaling, metabolism, and function

J Rowlands, J Heng, P Newsholme… - Frontiers in …, 2018 - frontiersin.org
The incretin hormone Glucagon-Like Peptide-1 (GLP-1) is best known for its “incretin effect”
in restoring glucose homeostasis in diabetics, however, it is now apparent that it has a …

Insulin resistance and Parkinson's disease: a new target for disease modification?

D Athauda, T Foltynie - Progress in neurobiology, 2016 - Elsevier
There is growing evidence that patients with Type 2 diabetes have an increased risk of
developing Parkinson's disease and share similar dysregulated pathways suggesting …

[HTML][HTML] The glucagon-like peptide 1 (GLP) receptor as a therapeutic target in Parkinson's disease: mechanisms of action

D Athauda, T Foltynie - Drug discovery today, 2016 - Elsevier
Highlights•GLP-1 analogs can cross the blood–brain barrier and stimulate the GLP-1
receptor in the brain.•Stimulation of the GLP-1 receptor has shown effects on mitochondrial …