Human milk oligosaccharides: health benefits, potential applications in infant formulas, and pharmacology

M Wiciński, E Sawicka, J Gębalski, K Kubiak… - Nutrients, 2020 - mdpi.com
The first months of life are a special time for the health development and protection of
infants. Breastfeeding is the natural and best way of feeding an infant, and positively …

Milk intelligence: Mining milk for bioactive substances associated with human health

S Mills, RP Ross, C Hill, GF Fitzgerald… - International dairy journal, 2011 - Elsevier
Milk has evolved as a complete food for the mammalian nourishment of its young. However,
research is unveiling an ever-accumulating range of bioactivities associated with milk …

Direct evidence for the presence of human milk oligosaccharides in the circulation of breastfed infants

KC Goehring, AD Kennedy, PA Prieto, RH Buck - PloS one, 2014 - journals.plos.org
Background It has been hypothesized that human milk oligosaccharides (HMOs) confer
systemic health benefits to breastfed infants; however, plausible mechanisms for some …

Production of human milk oligosaccharides by enzymatic and whole-cell microbial biotransformations

GA Sprenger, F Baumgärtner, C Albermann - Journal of biotechnology, 2017 - Elsevier
Human milk oligosaccharides (HMO) are almost unique constituents of breast milk and are
not found in appreciable amounts in cow milk. Due to several positive aspects of HMO for …

The influence of milk oligosaccharides on microbiota of infants: opportunities for formulas

M Chichlowski, JB German, CB Lebrilla… - Annual review of food …, 2011 - annualreviews.org
In addition to a nutritive role, human milk also guides the development of a protective
intestinal microbiota in the infant. Human milk possesses an overabundance of complex …

Milk oligosaccharides: A review

DL Oliveira, RA Wilbey, AS Grandison… - … Journal of Dairy …, 2015 - Wiley Online Library
Milk oligosaccharides (OS s) confer unique health benefits to the neonate. Although human
digestive enzymes cannot degrade these sugars, they support specific commensal microbes …

Functional glycomic analysis of human milk glycans reveals the presence of virus receptors and embryonic stem cell biomarkers

Y Yu, S Mishra, X Song, Y Lasanajak… - Journal of Biological …, 2012 - ASBMB
Human milk contains a large diversity of free glycans beyond lactose, but their functions are
not well understood. To explore their functional recognition, here we describe a shotgun …

OMICS-rooted studies of milk proteins, oligosaccharides and lipids

B Casado, M Affolter, M Kussmann - Journal of proteomics, 2009 - Elsevier
Milk has co-evolved with mammals and mankind to nourish their offspring and is a biological
fluid of unique complexity and richness. It contains all necessary nutrients for the growth and …

Pre-clinical safety evaluation of the synthetic human milk, nature-identical, oligosaccharide 2′-O-Fucosyllactose (2′ FL)

M Coulet, P Phothirath, L Allais, B Schilter - Regulatory Toxicology and …, 2014 - Elsevier
In order to match the composition of human breast milk more closely, it is now possible to
supplement commercial infant formula (IF) with synthesised oligosaccharides that are …

The role of oligosaccharides from human milk and other sources in prevention of pathogen adhesion

RM Hickey - International Dairy Journal, 2012 - Elsevier
Adhesion of pathogens is required for colonization and subsequent development of disease,
and when adhered, they are more likely to survive, as their resistance to cleansing …