Our ability to detect, image, and quantify nanoscopic objects and molecules with visible light
has undergone dramatic improvements over the past few decades. While fluorescence has …

Membrane proteins (MPs) play essential roles in numerous cellular processes. Because
around 70% of the currently marketed drugs target MPs, a detailed understanding of their …

Membrane proteins are a highly relevant class of biological molecules and comprise∼ 60%
of current drug targets. Before being analyzed by structural, biochemical, and biophysical …

Mass photometry (MP) is a relatively new experimental technique with a quickly expanding
list of applications. Using optical detection, MP measures the mass of individual molecules …

Abstract Glycine Receptors (GlyRs) provide inhibitory neuronal input in the spinal cord and
brainstem, which is critical for muscle coordination and sensory perception. Synaptic GlyRs …

Membrane proteins can be examined in near‐native lipid‐bilayer environments with the
advent of polymer‐encapsulated nanodiscs. These nanodiscs self‐assemble directly from …

Recombinant adeno-associated viruses (rAAV) are used extensively as gene delivery
vectors in clinical studies, and several rAAV based treatments have already been approved …

Cryo–electron microscopy (cryo-EM) continues its remarkable growth as a method for
visualizing biological objects, which has been driven by advances across the entire pipeline …

We review recent advances in our ability to characterise biomolecular structure, interactions
and associated dynamics by mass photometry (MP), the label-free detection and mass …

Successful sample preparation is the foundation to any structural biology technique.
Membrane proteins are of particular interest as these are important targets for drug design …