A review on recent approaches on molecular docking studies of novel compounds targeting acetylcholinesterase in Alzheimer disease
SC Peitzika, E Pontiki - Molecules, 2023 - mdpi.com
Alzheimer's disease (AD), a neurodegenerative brain disorder that affects millions of people
worldwide, is characterized by memory loss and cognitive decline. Low levels of …
worldwide, is characterized by memory loss and cognitive decline. Low levels of …
Design, synthesis, in vitro anticancer and antimicrobial evaluation, SAR analysis, molecular docking and dynamic simulation of new pyrazoles, triazoles and …
HA Radwan, I Ahmad, IMM Othman… - Journal of Molecular …, 2022 - Elsevier
A new series of pyrazoles, triazoles and pyridazines based isoxazole were synthesized, and
well characterized. Their antibacterial, antifungal and cytotoxic activities were successfully …
well characterized. Their antibacterial, antifungal and cytotoxic activities were successfully …
In vitro evaluation and bioinformatics analysis of schiff bases bearing pyrazole scaffold as bioactive agents: antioxidant, anti-diabetic, anti-alzheimer, and anti-arthritic
In continuation of our research programs for the discovery, production, and development of
the pharmacological activities of molecules for various disease treatments, Schiff bases and …
the pharmacological activities of molecules for various disease treatments, Schiff bases and …
[HTML][HTML] Therapeutic role of columbianadin in human disorders: Medicinal importance, biological properties and analytical aspects
DK Patel - Pharmacological Research-Modern Chinese Medicine, 2023 - Elsevier
Introduction Herbal medicines have been used for the treatment of human disorders and
associated secondary complications since a very early age. Herbal medicines are …
associated secondary complications since a very early age. Herbal medicines are …
Pyrazolo-imidazolidinones: Synthesis, antimicrobial assessment and molecular modelling studies by molecular mechanic and quantum mechanic approach
Antimicrobial resistance (AMR) and multidrug resistance (MDR) have become global
therapeutic barriers and due to this, there is increasing global mortality. To overcome …
therapeutic barriers and due to this, there is increasing global mortality. To overcome …
Diverse and efficient catalytic applications of new cockscomb flower-like Fe 3 O 4@ SiO 2@ KCC-1@ MPTMS@ Cu II mesoporous nanocomposite in the …
MH Galehban, B Zeynizadeh, H Mousavi - RSC advances, 2022 - pubs.rsc.org
In this research, Fe3O4@ SiO2@ KCC-1@ MPTMS@ CuII as a new cockscomb flower-like
mesoporous nanocomposite was prepared and characterized by various techniques …
mesoporous nanocomposite was prepared and characterized by various techniques …
[HTML][HTML] Synthesis, in silico ADMET prediction analysis, and pharmacological evaluation of sulfonamide derivatives tethered with pyrazole or pyridine as anti-diabetic …
NM Abdelazeem, WM Aboulthana, AS Hassan… - Saudi Pharmaceutical …, 2024 - Elsevier
Based on previous developments of our research programs in trying to find new compounds
with multiple biological targets such as antioxidant, anti-diabetic, anti-Alzheimer's, and anti …
with multiple biological targets such as antioxidant, anti-diabetic, anti-Alzheimer's, and anti …
Highly efficient, catalyst-free, one-pot sequential four-component synthesis of novel spiroindolinone-pyrazole scaffolds as anti-Alzheimer agents: in silico study and …
H Pourtaher, Y Mohammadi, A Hasaninejad… - RSC Medicinal …, 2024 - pubs.rsc.org
Alzheimer's disease is a neurodegenerative disorder that impacts memory, thinking, and
behavior, and currently, there is no effective cure available for its treatment. This study …
behavior, and currently, there is no effective cure available for its treatment. This study …
Synthesis, in vitro biological investigation, and in silico analysis of pyrazole-based derivatives as multi-target agents
AS Hassan, WM Aboulthana - Egyptian Journal of Chemistry, 2023 - journals.ekb.eg
The diseases-related complications and causes are threaded. Accordingly, the preparation
of one drug with multiple targets is very pressing. In this context, the three series of pyrazole …
of one drug with multiple targets is very pressing. In this context, the three series of pyrazole …
[HTML][HTML] Exploring facile synthesis and cholinesterase inhibiting potential of heteroaryl substituted imidazole derivatives for the treatment of Alzheimer's disease
Alzheimer's disease (AD) is a neurodegenerative disorder and cholinesterase (ChE)
enzymes are considered as crucial targets for the treatment of AD. Herein, a series of …
enzymes are considered as crucial targets for the treatment of AD. Herein, a series of …