Mammalian oocytes undergo two rounds of developmental arrest during maturation: at the
diplotene of the first meiotic prophase and metaphase of the second meiosis. These arrests …

Although the involvement of the extracellular signal-regulated kinases 1 and 2 (ERK1/2)
pathway in the regulation of cytostatic factor (CSF) activity; as well as in microtubules …

Simple Summary Current knowledge about the downstream substrate proteins of MAPKs is
still limited. Our study screened a new WRKY IIa transcription factor as the substrate protein …

Controlled mRNA storage and stability is essential for oocyte meiosis and early embryonic
development. However, how to regulate mRNA storage and stability in mammalian …

In vitro maturation of porcine oocytes is characterized by asynchronous cytoplasmic and
nuclear maturation, leading to less competent oocytes supporting embryo development. The …

Cisplatin is a widely used anti-cancer drug. However, cisplatin is limited in clinical treatment
because of its severe nephrotoxicity. This study reported whether O-GSP can antagonize the …

In mammals, journey from metaphase‐I (M‐I) to metaphase‐II (M‐II) is important since
oocyte extrude first polar body (PB‐I) and gets converted into haploid gamete. The …

The MPF and MAPK genes play crucial roles during oocyte maturation processes. However,
the pattern of MPF and MAPK gene expression induced by melatonin (MT) and its …

In mammals, including humans, mature oocytes are ovulated into the oviduct for fertilization.
Normally, these oocytes are arrested at metaphase of the second meiosis (MII), and this …

Background To achieve oocyte competence for successful fertilization, bidirectional
communication between oocyte and granulosa cells is crucial. The acquisition of meiotic …