Cyclooxygenase-2 (COX-2) as a target of anticancer agents: A review of novel synthesized scaffolds having anticancer and COX-2 inhibitory potentialities
Cancer is a serious threat to human beings and is the second-largest cause of death all over
the globe. Chemotherapy is one of the most common treatments for cancer; however, drug …
the globe. Chemotherapy is one of the most common treatments for cancer; however, drug …
Chemistry and biological activities of 1, 2, 4-triazolethiones—antiviral and anti-infective drugs
Mercapto-substituted 1, 2, 4-triazoles are very interesting compounds as they play an
important role in chemopreventive and chemotherapeutic effects on cancer. In recent …
important role in chemopreventive and chemotherapeutic effects on cancer. In recent …
Synthesis, molecular modeling, in vivo study, and anticancer activity of 1,2,4‐triazole containing hydrazide–hydrazones derived from (S)‐naproxen
Abstract A new series of 1, 2, 4‐triazole containing hydrazide–hydrazones derived from (S)‐
naproxen (7a–m) was synthesized in this study. The structures of these compounds were …
naproxen (7a–m) was synthesized in this study. The structures of these compounds were …
Synthesis, molecular modeling, in vivo study and anticancer activity against prostate cancer of (+)(S)-naproxen derivatives
Abstract In this study,(S)-naproxen thiosemicarbazides (3a-d), 1, 2, 4-triazoles (4a-c),
triazole-thioether hybride compounds (5a-p) were synthesized and their structures (3a, 3d …
triazole-thioether hybride compounds (5a-p) were synthesized and their structures (3a, 3d …
Synthesis and anthelmintic activity of new thiosemicarbazide derivatives—A preliminary study
K Dziduch, P Kołodziej, A Paneth, A Bogucka-Kocka… - Molecules, 2020 - mdpi.com
Parasitic infections caused by different species of intestinal helminths still poses a threat to
public health. There is a need to search for new, effective anthelmintic drugs. A series of …
public health. There is a need to search for new, effective anthelmintic drugs. A series of …
Design, synthesis, and biological evaluation of new celecoxib analogs as apoptosis inducers and cyclooxygenase‐2 inhibitors
EF Abdelhaleem, AE Kassab… - Archiv der …, 2022 - Wiley Online Library
Abstract Series of new celecoxib analogs were synthesized to assess their anticancer
activity against the MCF‐7 cell line. Four compounds, 3a, 3c, 5b, and 5c, showed 1.4–9.2 …
activity against the MCF‐7 cell line. Four compounds, 3a, 3c, 5b, and 5c, showed 1.4–9.2 …
Design, synthesis, and in vitro and in vivo anticancer activity studies of new (S)-Naproxen thiosemicarbazide/1, 2, 4-triazole derivatives
In this study, a series of novel (S)-Naproxen derivatives bearing a thiosemicarbazide/1, 2, 4-
triazole moiety were designed, synthesized, and evaluated for anticancer activity. The …
triazole moiety were designed, synthesized, and evaluated for anticancer activity. The …
Synthesis and molecular modeling of MetAP2 of thiosemicarbazides, 1, 2, 4-triazoles, thioethers derived from (S)-Naproxen as possible breast cancer agents
Abstract New thiosemicarbazides (3, 5-6), 1, 2, 4-triazoles (14-15) and thioethers (22-68)
from derived (S)-Naproxen were synthesized in this study. The structure of these compounds …
from derived (S)-Naproxen were synthesized in this study. The structure of these compounds …
NOS2 and COX-2 Co-Expression Promotes Cancer Progression: A Potential Target for Developing Agents to Prevent or Treat Highly Aggressive Breast Cancer
LL Coutinho, EL Femino, AL Gonzalez… - International Journal of …, 2024 - mdpi.com
Nitric oxide (NO) and reactive nitrogen species (RNS) exert profound biological impacts
dictated by their chemistry. Understanding their spatial distribution is essential for …
dictated by their chemistry. Understanding their spatial distribution is essential for …
New Thiosemicarbazide Derivatives with Multidirectional Biological Action
P Lasek, U Kosikowska, P Kołodziej… - Molecules, 2024 - mdpi.com
Over the years, several new medicinal substances have been introduced for the treatment of
diseases caused by bacteria and parasites. Unfortunately, due to the production of …
diseases caused by bacteria and parasites. Unfortunately, due to the production of …