Replica-exchange molecular dynamics (REMD) and their variants have been widely used in
simulations of the biomolecular structure and dynamics. Replica exchange with solute …

Promiscuous recognition of ligands by proteins is as important as strict recognition in
numerous biological processes. In living cells, many short, linear amino acid motifs function …

The presequence translocase TIM23 is a highly dynamic complex in which its subunits can
adopt multiple conformations and undergo association-dissociation to facilitate import of …

The graphics processing unit (GPU) has become a popular computational platform for
molecular dynamics (MD) simulations of biomolecules. A significant speedup in the …

In the genetic modification of plant cells, the mitochondrion is an important target in addition
to the nucleus and plastid. However, gene delivery into the mitochondria of plant cells has …

Background Tim21, a subunit of a highly dynamic translocase of the inner mitochondrial
membrane (TIM23) complex, translocates proteins by interacting with subunits in the …

Contacts with neighboring molecules in protein crystals inevitably restrict the internal
motions of intrinsically flexible proteins. The resultant clear electron densities permit model …

An all atomic, non-restrained molecular dynamics (MD) simulation in explicit water was used
to study in detail the structural features of the highly conserved glycine-rich loop (GRL) of the …

The translocase of the outer membrane (TOM) mediates the membrane permeation of
mitochondrial matrix proteins. Tom20 is a subunit of the TOM complex and binds to the N …

Objetivo: identificar, describir y diferenciar las características fenotípicas de los fibroblastos
gingivales (FGs) en pacientes con hiperplasia gingival idiopática (HGI) e individuos …