From the start of a synthetic chemist's training, experiments are conducted based on recipes
from textbooks and manuscripts that achieve clean reaction outcomes, allowing the scientist …

Self-driving laboratories (SDLs) promise an accelerated application of the scientific method.
Through the automation of experimental workflows, along with autonomous experimental …

Monoligated palladium (0) species, L1Pd (0), have emerged as the most active catalytic
species in the cross-coupling cycle. Today, there are methods available to generate the …

Functionalization of C–H bonds is a key challenge in medicinal chemistry, particularly for
fragment-based drug discovery (FBDD) where such transformations require execution in the …

Photoredox catalysis has emerged as a powerful and versatile platform for the synthesis of
complex molecules. While photocatalysis is already broadly used in small-scale batch …

Autonomous flow reactors are becoming increasingly utilized in the synthesis of organic
compounds, yet the complexity of the chemical reactions and analytical methods remains …

In the fine chemicals industry, reaction screening and optimisation are essential to
development of new products. However, this screening can be extremely time and labor …

Organic superbases are a distinct and increasingly utilized class of Brønsted base that
possess properties complementary to common inorganic bases. This Concept article …

Bayesian optimization is a powerful machine learning technique that is particularly well-
suited for optimizing chemical reactions in the early stages of process development. It can …

Abstract A highly effective C− O coupling reaction of (hetero) aryl electrophiles with primary
and secondary alcohols is reported. Catalyzed by a NiII‐aryl complex under long‐wave UV …