The molecular mechanism of vitamin E as a bone-protecting agent: a review on current evidence

SK Wong, NV Mohamad, NI Ibrahim, KY Chin… - International journal of …, 2019 - mdpi.com
Bone remodelling is a tightly-coordinated and lifelong process of replacing old damaged
bone with newly-synthesized healthy bone. In the bone remodelling cycle, bone resorption …

Natural food dyes on dairy products: A critical approach between 2012-2023 literature regarding the technological and functional aspects, health benefits and future …

MEM Soutelino, G de Paiva Vieira, MB Goulart… - Trends in Food Science …, 2024 - Elsevier
Background Synthetic dyes consumption, such as tartrazine, quinoline yellow, sunset
yellow, azorubine, ponceau 4 R, erythrosine, allura red, patent blue, indigo carmine, brilliant …

[HTML][HTML] Therapeutic potential of annatto tocotrienol with self-emulsifying drug delivery system in a rat model of postmenopausal bone loss

NV Mohamad, S Ima-Nirwana, KY Chin - Biomedicine & Pharmacotherapy, 2021 - Elsevier
Tocotrienol has been shown to prevent bone loss in animal models of postmenopausal
osteoporosis, but the low oral bioavailability might limit its use. A self-emulsifying drug …

[HTML][HTML] Effects of emulsified and non-emulsified palm tocotrienol on bone and joint health in ovariectomised rats with monosodium iodoacetate-induced osteoarthritis

SO Ekeuku, MLN Muhamad, AA Aminuddin… - Biomedicine & …, 2024 - Elsevier
Postmenopausal women are susceptible to osteoporosis and osteoarthritis. Tocotrienol, a
bone-protective nutraceutical, is reported to prevent osteoarthritis in male rats. However, its …

Tocotrienol as a protecting agent against glucocorticoid-induced osteoporosis: a mini review of potential mechanisms

SO Ekeuku, ES Mohd Ramli, N Abdullah Sani… - Molecules, 2022 - mdpi.com
Glucocorticoid-induced osteogenic dysfunction is the main pathologyical mechanism
underlying the development of glucocorticoid-induced osteoporosis. Glucocorticoids …

[HTML][HTML] Self-emulsified annatto tocotrienol improves bone histomorphometric parameters in a rat model of oestrogen deficiency through suppression of skeletal …

NV Mohamad, S Ima-Nirwana… - International Journal of …, 2021 - ncbi.nlm.nih.gov
Menopause is the leading cause of osteoporosis for elderly women due to imbalanced bone
remodelling in the absence of oestrogen. The ability of tocotrienol in reversing established …

Beneficial effects of δ-tocotrienol against oxidative stress in osteoblastic cells: Studies on the mechanisms of action

L Casati, F Pagani, P Limonta, C Vanetti… - European journal of …, 2020 - Springer
Purpose Natural antioxidants are considered as promising compounds in the
prevention/treatment of osteoporosis. We studied the ability of purified δ-tocotrienol (δ-TT) …

Annatto-derived tocotrienol stimulates osteogenic activity in preosteoblastic MC3T3-E1 cells: A temporal sequential study

WN Wan Hasan, N Abd Ghafar, KY Chin… - Drug design …, 2018 - Taylor & Francis
Purpose Annatto-derived tocotrienol (AnTT) has been shown to improve bone formation in
animal models of osteoporosis. However, detailed studies of the effects of AnTT on …

The role of tocotrienol in preventing male osteoporosis—A review of current evidence

KY Chin, S Ima-Nirwana - International journal of molecular sciences, 2019 - mdpi.com
Male osteoporosis is a significant but undetermined healthcare problem. Men suffer from a
higher mortality rate post-fracture than women and they are marginalized in osteoporosis …

Food for bone: evidence for a role for delta-tocotrienol in the physiological control of osteoblast migration

L Casati, F Pagani, R Maggi, F Ferrucci… - International Journal of …, 2020 - mdpi.com
Bone remodeling and repair require osteogenic cells to reach the sites that need to be
rebuilt, indicating that stimulation of osteoblast migration could be a promising …